THOC1

Gene Symbol THOC1
Entrez Gene 9984
Alt Symbol HPR1, P84, P84N5
Species Human
Gene Type protein-coding
Description THO complex 1
Other Description THO complex subunit 1|hTREX84|nuclear matrix protein p84|tho1
Swissprots Q15219 Q64I72 Q96FV9 Q64I73 B2RBP6
Accessions EAX01731 EAX01732 EAX01733 EAX01734 Q96FV9 AK055354 AK123530 AK225067 AK225709 AK314755 BAG37293 AY573302 AAT81408 AY573303 AAT81409 BC010381 AAH10381 DA902294 DQ892768 ABM83694 EU176747 ABW03548 L36529 AAA53571 XM_011525772 XP_011524074 XM_011525773 XP_011524075 XM_011525774 XP_011524076 NM_005131 NP_005122
Function Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.
Subcellular Location Isoform 1: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution.
Tissue Specificity Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression. {ECO:0000269|PubMed:15358532, ECO:0000269|PubMed:15833825}.
Top Pathways Spliceosome, RNA transport

THOC1 CRISPR/Cas9 KO Plasmid (h) - sc-403390 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC1 HDR Plasmid (h) - sc-403390-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC1 Double Nickase Plasmid (h) - sc-403390-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC1 Double Nickase Plasmid (h2) - sc-403390-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC1 CRISPR Activation Plasmid (h) - sc-403390-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC1 CRISPR Activation Plasmid (h2) - sc-403390-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC1 Lentiviral Activation Particles (h) - sc-403390-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC1 Lentiviral Activation Particles (h2) - sc-403390-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC1 siRNA (h) - sc-76652 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

THOC1 shRNA Plasmid (h) - sc-76652-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

THOC1 shRNA (h) Lentiviral Particles - sc-76652-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

hHpr1-p84-Thoc1 RNAi - H00009984-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU050761 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21314 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21314 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

THOC1 siRNA (Human) - CRH6716 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

THOC1 - MBS8204493 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human THOC1(NM_005131.2) - SHL069318 from Creative biogene

Category siRNA
Species Reactivities Human

THOC1 shRNA Plasmid (Human) - CHH6716 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

THOC1 miRNA 3'UTR clone - MiUTR1H-10381 from Creative biogene

Species Reactivities Human
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