NEU2
| Gene Symbol | NEU2 |
|---|---|
| Entrez Gene | 4759 |
| Alt Symbol | SIAL2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sialidase 2 (cytosolic sialidase) |
| Other Description | N-acetyl-alpha-neuraminidase 2|cytosolic sialidase|neuraminidase 2|sialidase-2 |
| Swissprots | Q3KNW4 Q9Y3R4 Q6NTB4 |
| Accessions | AAY24360 CAB41449 EAW71028 Q9Y3R4 BC069151 AAH69151 BC107053 AAI07054 XM_011511241 XP_011509543 NM_005383 NP_005374 |
| Function | Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides. {ECO:0000269|PubMed:14613940, ECO:0000269|PubMed:22228546}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1. {ECO:0000269|PubMed:10191093}. |
| Top Pathways | Sphingolipid metabolism, Other glycan degradation |
Neu2 (37Y) - sc-100570 from Santa Cruz Biotechnology
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Neu2 (A-20) - sc-168733 from Santa Cruz Biotechnology
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Anti-NEU2 antibody - ab110515 from Abcam
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Anti-NEU2 antibody - ab55568 from Abcam
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Anti-NEU2 / Sialidase 2 Antibody (aa23-50, AP) - LS-C237968 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (clone 8C12) - LS-C173198 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (clone 3G9) - LS-C197768 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (aa110-124) - LS-C60084 from LifeSpan Bioscience
![Anti-Neu2 Antibody - Western Blot. Western blot of Affinity Purified anti-Neu2 antibody to detect Neu-2 present in a lysate expressing human Neu2 (1.0 ul loaded). Molecular weight marker (not shown) indicates a band of the expected MW (43 kD). The reactive lower molecular weight band is believed to represent a truncated form of this protein. The blot was incubated with a 1:500 dilution of the antibody at room temperature for 1 h followed by detection using IRDye800 labeled Goat-a-Rabbit IgG [H&L] ( diluted 1:1000. IRDye800 fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.](http://www.bioprodhub.com/system/product_images/ab_products/3/sub_4/9910_62888_1262378.jpg)
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Anti-NEU2 / Sialidase 2 Antibody (aa23-50, APC) - LS-C237969 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (aa23-50, Biotin) - LS-C237970 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (aa23-50, FITC) - LS-C237971 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (aa23-50, PE) - LS-C237975 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (aa23-50, Azide-free, HRP) - LS-C248899 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (aa30-58) - LS-C323299 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (clone 5E1) - LS-C172771 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (aa119-168) - LS-C206290 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (clone 4F4) - LS-C172974 from LifeSpan Bioscience
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Anti-NEU2 / Sialidase 2 Antibody (aa23-50) - LS-C164833 from LifeSpan Bioscience
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NEU2 Antibody - NBP2-30039 from Novus Biologicals
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NEU2 Antibody (4F4) - NBP2-00783 from Novus Biologicals
![Western Blot: NEU2 Antibody (4F4) [NBP2-00783] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY NEU2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-NEU2.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_8/29535_NEU2%2520Antibody%2520(4F4)-Western%2520Blot-NBP2-00783-img0002.jpg)
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NEU2 Antibody - NBP2-21649 from Novus Biologicals
![Western Blot: NEU2 Antibody [NBP2-21649] - Affinity Purified anti-Neu2 antibody to detect recombinant His tagged Neu-2. Molecular weight marker indicates a single band of the expected MW. The blot was incubated with a 1:500 dilution of the antibody at room temperature for 1 h followed by detection using InfraRed Dye 800 labeled Goat-a-Rabbit IgG [H&L] diluted 1:1000. Other detection systems will yield similar results.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_10/5009_NEU2-Antibody-Western-Blot-NBP2-21649-img0002.jpg)
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NEU2 Antibody (3B9) - H00004759-M03 from Novus Biologicals
![Western Blot: NEU2 Antibody (3B9) [H00004759-M03] - NEU2 monoclonal antibody (M03), clone 3B9. Western Blot analysis of NEU2 expression in human fetal liver.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_4/22080_NEU2-Antibody-%25283B9%2529-Western-Blot-H00004759-M03-img0003.jpg)
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NEU2 Antibody (2E5.) - H00004759-M04 from Novus Biologicals
![ELISA: NEU2 Antibody (2E5) [H00004759-M04] - Detection limit for recombinant GST tagged NEU2 is approximately 3ng/ml as a capture antibody.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_10/20277_NEU2-Antibody-(2E5)-ELISA-H00004759-M04-img0001.jpg)
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NEU2 Antibody - H00004759-A01 from Novus Biologicals
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NEU2 Antibody (3G9) - H00004759-M02 from Novus Biologicals
![Sandwich ELISA: NEU2 Antibody (3G9) [H00004759-M02] - Detection limit for recombinant GST tagged NEU2 is approximately 1ng/ml as a capture antibody.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_10/21861_NEU2%2520Antibody%2520(3G9)-Sandwich%2520ELISA-H00004759-M02-img0002.jpg)
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