Trp53

Gene Symbol Trp53
Entrez Gene 22059
Alt Symbol Tp53, bbl, bfy, bhy, p44, p53
Species Mouse
Gene Type protein-coding
Description transformation related protein 53
Other Description cellular tumor antigen p53|mutant p53|p53 cellular tumor antigen|tumor suppressor p53|tumor supressor p53
Swissprots Q9QUP3 P02340
Accessions AAB21108 AAC71763 AAC71764 AAF43275 AAF43276 AAK53397 ABQ44583 ABR29561 CAA25420 CAI52015 CAI52016 CDM63358 EDL10505 EDL10506 EDL10507 P02340 AB017815 BAA82339 AB017816 BAA82340 AB020317 BAA82343 AB021961 BAA82344 AB221571 AF051368 AAC05704 AF151353 AAD39535 AF161020 AAD44340 AI323249 AJ297973 CAC17147 AK079711 BAC37729 AK083750 AK086845 AK087834 AK138777 BAE23775 AK147815 BAE28156 AK190460 AK191352 AK194492 AV450598 AY044188 AAK94783 AY212017 AAO60156 AY423848 AAR00340 BC005448 AAH05448 D63399 EU031806 ABS81351 GU808447 KF766124 AHH81944 M13872 AAA39881 M13873 AAA39882 M13874 AAA39883 U59757 AAB03323 X00741 CAA25323 X01237 CAA25625 XM_006533157 XP_006533220 NM_001127233 NP_001120705 NM_011640 NP_035770
Function Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression (By similarity). Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but s
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Note=Interaction with BANP promotes nuclear localization. Translocates to mitochondria upon oxidative stress (By similarity). {ECO:0000250}.
Top Pathways Proteoglycans in cancer, Sphingolipid signaling pathway, Cell cycle, Central carbon metabolism in cancer, p53 signaling pathway

Phospho-p53 (Ser15) (D4S1H) Rabbit mAb (Rodent Specific) - 12571 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl
Host Rabbit
Clonality Monoclonal
Clone D4S1H
Western blot analysis of extracts from L-929 cells, untreated (-) or treated with Etoposide #2200 (30 μM, 2 hr; +), using Phospho-p53 (Ser15) (D4S1H) Rabbit mAb (Rodent Specific). To characterize the phospho-specificity of the antibody, the blot was mock treated (-) or treated (+) with calf intestinal phosphatase (CIP).

p53 (A-1) - sc-393031 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p53 (A-1): sc-393031. Western blot analysis of p53 expression in WR19L whole cell lysate.

p53 (Pab 246) - sc-100 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p53 (Pab 246): sc-100. Western blot analysis of p53 expression in mouse Lac Z whole cell lysate.

p53 (3H2821) - sc-56179 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p53 (3H2821): sc-56179. Western blot analysis of p53 expression in mouse Lac Z whole cell lysate.

p53 (R-19) - sc-1313 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p53 (R-19): sc-1313. Western blot analysis of p53 expression in A-431 (A), WR19L (B) and mouse Lac Z (C) whole cell lysates. Note lack of reactivity with human p53 in lane A.

p53 (E-19) - sc-1315 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p53 (E-19): sc-1315. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing nuclear localization.

p53 (3H2821) - sc-71815 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p53 (3H2821): sc-71815. Western blot analysis of p53 expression in mouse Lac Z whole cell lysate.

p-p53 (mSer 20) - sc-18078 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-p53 (mSer 20)-R: sc-18078-R. Western blot analysis of p53 phosphorylation in untreated (A) and UV-treated (B) COS whole cell lysates.

Anti-TRP53 antibody produced in rabbit - AV37163 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: SP20 (<B>Cat. No. AV37163</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 2.5 μg/mL in cell type SP20

Anti-TRP53 antibody produced in rabbit - SAB2106418 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TRP53: <B>Cat. No. SAB2106418</B>: Western blot analysis of Trp53 with Trp53 (transformation related protein 53) antibody against the n terminal of Trp53 (50 μg) antibody at 1.0 μg/mL.

Trp53 Antibody (OASA03559) - OASA03559 from Aviva Systems Biology

Prices $410.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone PAb246

TRP53 antibody - C-terminal region (ARP37163_T100) - ARP37163_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Trp53 antibody - N-terminal region (ARP37897_P050) - ARP37897_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

p53 antibody (Ser376) - 70R-32612 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

P53 antibody (Ser20) - 70R-37414 from Fitzgerald

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

p53 antibody (Ser20) - 70R-35201 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

p53 antibody - 70R-35291 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

p53 antibody - 70R-37523 from Fitzgerald

Prices $225.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

TP53 Polyclonal Antibody - A5761 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using TP53 antibody.

p53 antibody (Ser6) - 70R-37173 from Fitzgerald

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

p53 antibody - 70R-36652 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

p53 antibody - 70R-31561 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

p53 antibody (Ser378) - 70R-32614 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

TP53 Antibody - abx004409 from Abbexa

Host Rabbit
Clonality Polyclonal

TP53 / p53 (Wild type) antibody - BM665P from Acris Antibodies

Prices $400.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Pab 246
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