Trp53
| Gene Symbol | Trp53 |
|---|---|
| Entrez Gene | 22059 |
| Alt Symbol | Tp53, bbl, bfy, bhy, p44, p53 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | transformation related protein 53 |
| Other Description | cellular tumor antigen p53|mutant p53|p53 cellular tumor antigen|tumor suppressor p53|tumor supressor p53 |
| Swissprots | Q9QUP3 P02340 |
| Accessions | AAB21108 AAC71763 AAC71764 AAF43275 AAF43276 AAK53397 ABQ44583 ABR29561 CAA25420 CAI52015 CAI52016 CDM63358 EDL10505 EDL10506 EDL10507 P02340 AB017815 BAA82339 AB017816 BAA82340 AB020317 BAA82343 AB021961 BAA82344 AB221571 AF051368 AAC05704 AF151353 AAD39535 AF161020 AAD44340 AI323249 AJ297973 CAC17147 AK079711 BAC37729 AK083750 AK086845 AK087834 AK138777 BAE23775 AK147815 BAE28156 AK190460 AK191352 AK194492 AV450598 AY044188 AAK94783 AY212017 AAO60156 AY423848 AAR00340 BC005448 AAH05448 D63399 EU031806 ABS81351 GU808447 KF766124 AHH81944 M13872 AAA39881 M13873 AAA39882 M13874 AAA39883 U59757 AAB03323 X00741 CAA25323 X01237 CAA25625 XM_006533157 XP_006533220 NM_001127233 NP_001120705 NM_011640 NP_035770 |
| Function | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression (By similarity). Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but s |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Note=Interaction with BANP promotes nuclear localization. Translocates to mitochondria upon oxidative stress (By similarity). {ECO:0000250}. |
| Top Pathways | Proteoglycans in cancer, Sphingolipid signaling pathway, Cell cycle, Central carbon metabolism in cancer, p53 signaling pathway |
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