Trp53

Gene Symbol	Trp53
Entrez Gene	22059
Alt Symbol	Tp53, bbl, bfy, bhy, p44, p53
Species	Mouse
Gene Type	protein-coding
Description	transformation related protein 53
Other Description	cellular tumor antigen p53|mutant p53|p53 cellular tumor antigen|tumor suppressor p53|tumor supressor p53
Swissprots	Q9QUP3 P02340
Accessions	AAB21108 AAC71763 AAC71764 AAF43275 AAF43276 AAK53397 ABQ44583 ABR29561 CAA25420 CAI52015 CAI52016 CDM63358 EDL10505 EDL10506 EDL10507 P02340 AB017815 BAA82339 AB017816 BAA82340 AB020317 BAA82343 AB021961 BAA82344 AB221571 AF051368 AAC05704 AF151353 AAD39535 AF161020 AAD44340 AI323249 AJ297973 CAC17147 AK079711 BAC37729 AK083750 AK086845 AK087834 AK138777 BAE23775 AK147815 BAE28156 AK190460 AK191352 AK194492 AV450598 AY044188 AAK94783 AY212017 AAO60156 AY423848 AAR00340 BC005448 AAH05448 D63399 EU031806 ABS81351 GU808447 KF766124 AHH81944 M13872 AAA39881 M13873 AAA39882 M13874 AAA39883 U59757 AAB03323 X00741 CAA25323 X01237 CAA25625 XM_006533157 XP_006533220 NM_001127233 NP_001120705 NM_011640 NP_035770
Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression (By similarity). Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but s
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Note=Interaction with BANP promotes nuclear localization. Translocates to mitochondria upon oxidative stress (By similarity). {ECO:0000250}.
Top Pathways	Proteoglycans in cancer, Sphingolipid signaling pathway, Cell cycle, Central carbon metabolism in cancer, p53 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant human Cellular tumor antigen p53 (OPCA00727) - OPCA00727 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Mouse p53 protein - orb244599 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Mouse

Mouse Tumor Protein p53 Protein - abx069576 from Abbexa Category Protein Source E.coli Species Mouse

Tumor Protein p53 (TP53), Mouse - 20-7315 from ARP American Research Products Category Protein Prices $569.00 Sizes 50 µg Source E.coli Species Mouse

Recombinant mouse Cellular tumor antigen p53 - CSB-EP024077MO CSB-BP024077MO CSB-MP024077MO from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Mouse

Recombinant mouse Cellular tumor antigen p53 - CSB-EP024077MO from Cusabio Category Protein Source E.coli Species Mouse

Recombinant Mouse Cellular tumor antigen p53(Tp53) - CSB-YP024077MO CSB-BP024077MO CSB-MP024077MO from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Mouse

Recombinant Human His6-FLAG-p53 Protein, CF - SP-452 from R&D Systems Category Protein Prices $255.00 Sizes 20 µg Source E. coli -derived Contains an N-terminal 6-His and FLAG (DYKDDDDK) tag Species Human

Cellular tumor antigen p53, Recombinant Protein - MBS963888 from MyBioSource Category Protein Prices $110.00, $190.00, $285.00, $460.00, $750.00, $910.00, $1,040.00, $1,180.00, $1,220.00, $1,285.00, $1,315.00, $1,380.00, $1,895.00, $1,950.00, $2,100.00, $2,495.00 Sizes 100 µg (Yeast), 50 µg (E-Coli), 100 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Yeast), 50 µg (Baculovirus), 1 mg (E-Coli), 200 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 500 µg (Yeast), 500 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell

p53, mutant, Recombinant Protein - MBS636765 from MyBioSource Category Protein Prices $490.00, $595.00 Sizes 2 µg, 5 µg Source E Coli

Recombinant Mouse TRP53 Protein - TRP53-17432M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

Recombinant human Cellular tumor antigen p53 (OPCA00728) - OPCA00728 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

TP53 Recombinant Protein (OPCD07652) - OPCD07652 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Recombinant mouse Cellular tumor antigen p53 - AP70872 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Mouse

Cellular tumor antigen p53, Recombinant Protein - MBS9420764 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Mouse

p53 Mutant, Recombinant Protein - MBS5308862 from MyBioSource Category Protein Prices $840.00 Sizes 5 µg Source E Coli

TP53 Recombinant Protein (Mouse) (OPCA03971) - OPCA03971 from Aviva Systems Biology Category Protein Species Mouse

Recombinant Mouse Cellular tumor antigen p53 (Tp53) - RPC22153 from Biomatik Category Protein Prices $276.00, $505.00, $2,491.00 Sizes 50 µg, 100 µg, 1 mg Source E.coli Species Mouse

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