Trp53

Gene Symbol	Trp53
Entrez Gene	22059
Alt Symbol	Tp53, bbl, bfy, bhy, p44, p53
Species	Mouse
Gene Type	protein-coding
Description	transformation related protein 53
Other Description	cellular tumor antigen p53|mutant p53|p53 cellular tumor antigen|tumor suppressor p53|tumor supressor p53
Swissprots	Q9QUP3 P02340
Accessions	AAB21108 AAC71763 AAC71764 AAF43275 AAF43276 AAK53397 ABQ44583 ABR29561 CAA25420 CAI52015 CAI52016 CDM63358 EDL10505 EDL10506 EDL10507 P02340 AB017815 BAA82339 AB017816 BAA82340 AB020317 BAA82343 AB021961 BAA82344 AB221571 AF051368 AAC05704 AF151353 AAD39535 AF161020 AAD44340 AI323249 AJ297973 CAC17147 AK079711 BAC37729 AK083750 AK086845 AK087834 AK138777 BAE23775 AK147815 BAE28156 AK190460 AK191352 AK194492 AV450598 AY044188 AAK94783 AY212017 AAO60156 AY423848 AAR00340 BC005448 AAH05448 D63399 EU031806 ABS81351 GU808447 KF766124 AHH81944 M13872 AAA39881 M13873 AAA39882 M13874 AAA39883 U59757 AAB03323 X00741 CAA25323 X01237 CAA25625 XM_006533157 XP_006533220 NM_001127233 NP_001120705 NM_011640 NP_035770
Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression (By similarity). Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but s
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Note=Interaction with BANP promotes nuclear localization. Translocates to mitochondria upon oxidative stress (By similarity). {ECO:0000250}.
Top Pathways	Proteoglycans in cancer, Sphingolipid signaling pathway, Cell cycle, Central carbon metabolism in cancer, p53 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cellular tumor antigen p53, Tp53, Mouse, ELISA Kit - E0928m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

P53/tumor protein, p53/TP53, Mouse, ELISA Kit - CSB-E08335m from ARP American Research Products Category ELISA Kit Prices $565.00, $835.00, $837.00, $839.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 31.25 pg/ml Range 125 pg/ml-8000 pg/ml

Mouse TP53(Tumor Protein p53) ELISA Kit - E-EL-M1215 from Elabscience Category ELISA Kit Sensitivity 37.50 pg/mL Range 62.50—4000 pg/mL

Mouse TP53 (Tumor Protein 53) CLIA Kit - E-CL-M0673 from Elabscience Category CLIA Kit Sensitivity 9.38 pg/mL Range Average Recovery (%)

tumor protein p53, ELISA Kit - MBS701303 from MyBioSource Category ELISA Kit Prices $250.00, $575.00, $835.00, $3,040.00, $5,755.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 31.25 pg/ml Range 125 pg/ml-8000 pg/ml

Mouse p53/tumor protein,p53/TP53 ELISA Kit - CSB-E08335m from Cusabio Category ELISA Kit Sensitivity 31.25 pg/ml Range 125 pg/ml-8000 pg/ml

Mouse TP53(Tumor Protein p53) ELISA Kit - E-EL-M1215 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 37.5 pg/mL Range 62.5~4000 pg/mL

Mouse TP53 / p53 Mutant ELISA Kit (Sandwich ELISA) - LS-F23866 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 37.5 pg/ml Range 62.5-4000 pg/ml

Mouse TP53 ELISA Kit - abx575908 from Abbexa Category ELISA Kit Sensitivity 2.46 pg/ml Range 6.25 pg/ml - 400 pg/ml

TP53 - EKM2832 from Nordic BioSite Sensitivity 37.5pg/ml Range 62.5--4000pg/ml

Mouse Tp53 ELISA Kit - E047923 from Biobool Category ELISA Kit

TRP53 ELISA Kit (Mouse) (OKCD02946) - OKCD02946 from Aviva Systems Biology Category ELISA Kit Prices $515.00 Sizes 400 pg Sensitivity 2.46 pg/mL Range 6.25-400 pg/mL

Mouse Cellular tumor antigen p53 (TP53) ELISA Kit - AE59553MO from ARP American Research Products Category ELISA Kit Prices $612.00 Sizes 96 t Sensitivity 2.46 pg/mL Range 6.25-400 pg/mL

Cellular tumor antigen p53, ELISA Kit - MBS288669 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tumor Protein p53 (TP53) , ELISA Kit - MBS2087709 from MyBioSource Category ELISA Kit Prices $495.00, $745.00, $1,030.00, $4,250.00, $7,660.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.46pg/mL Range 6.25-400pg/mL

Tumor Protein p53 (TP53), ELISA Kit - MBS453728 from MyBioSource Category ELISA Kit Prices $395.00, $520.00, $2,275.00, $4,420.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.46pg/mL Range 6.25-400pg/mL

Mouse TP53 (Tumor Protein p53) ELISA Kit - EKE61819 from Biomatik Category ELISA Kit Prices $609.00 Sizes 96 tests Sensitivity 37.5 pg/mL Range 62.5-4000 pg/mL

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