| Gene Symbol |
SKA2
|
| Entrez Gene |
348235
|
| Alt Symbol |
FAM33A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spindle and kinetochore associated complex subunit 2
|
| Other Description |
family with sequence similarity 33, member A|spindle and KT (kinetochore) associated 2|spindle and kinetochore-associated protein 2
|
| Swissprots |
B3KPL3 Q8WVK7 E9PCB8 A6NIL3
|
| Accessions |
EAW94420 EAW94421 EAW94422 EAW94423 Q8WVK7 AK022820 AK056473 BAG51725 BC017873 AAH17873 BC106003 AAI06004 BQ019350 DA133216 DB158057 FJ648812 ACN41865 HQ447776 ADQ32261 XM_011524745 XP_011523047 NM_001100595 NP_001094065 NM_182620 NP_872426
|
| Function |
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins.
|