| Gene Symbol | SKA2 |
|---|---|
| Entrez Gene | 348235 |
| Alt Symbol | FAM33A |
| Species | Human |
| Gene Type | protein-coding |
| Description | spindle and kinetochore associated complex subunit 2 |
| Other Description | family with sequence similarity 33, member A|spindle and KT (kinetochore) associated 2|spindle and kinetochore-associated protein 2 |
| Swissprots | B3KPL3 Q8WVK7 E9PCB8 A6NIL3 |
| Accessions | EAW94420 EAW94421 EAW94422 EAW94423 Q8WVK7 AK022820 AK056473 BAG51725 BC017873 AAH17873 BC106003 AAI06004 BQ019350 DA133216 DB158057 FJ648812 ACN41865 HQ447776 ADQ32261 XM_011524745 XP_011523047 NM_001100595 NP_001094065 NM_182620 NP_872426 |
| Function | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}. |
| Subcellular Location | Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. |
Ska2 CRISPR/Cas9 KO Plasmid (h) - sc-405933 from Santa Cruz Biotechnology
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Ska2 HDR Plasmid (h) - sc-405933-HDR from Santa Cruz Biotechnology
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Ska2 Double Nickase Plasmid (h) - sc-405933-NIC from Santa Cruz Biotechnology
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Ska2 Double Nickase Plasmid (h2) - sc-405933-NIC-2 from Santa Cruz Biotechnology
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Ska2 CRISPR Activation Plasmid (h) - sc-405933-ACT from Santa Cruz Biotechnology
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Ska2 CRISPR Activation Plasmid (h2) - sc-405933-ACT-2 from Santa Cruz Biotechnology
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Ska2 Lentiviral Activation Particles (h) - sc-405933-LAC from Santa Cruz Biotechnology
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Ska2 Lentiviral Activation Particles (h2) - sc-405933-LAC-2 from Santa Cruz Biotechnology
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Ska2 siRNA (h) - sc-94176 from Santa Cruz Biotechnology
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Ska2 shRNA Plasmid (h) - sc-94176-SH from Santa Cruz Biotechnology
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Ska2 shRNA (h) Lentiviral Particles - sc-94176-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU025211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19374 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19374 from Sigma-Aldrich
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SKA2 siRNA (Human) - CRJ7531 from Cohesion Biosciences
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SKA2 - MBS8238897 from MyBioSource
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Ska2 CRISPR/Cas9 KO Plasmid (h2) - sc-405933-KO-2 from Santa Cruz Biotechnology
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Ska2 HDR Plasmid (h2) - sc-405933-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human SKA2 (NM_182620.3) - SHH407921 from Creative biogene
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shRNA set against Human FAM33A(NM_182620.3) - SHH046667 from Creative biogene
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SKA2 shRNA Plasmid (Human) - CHJ7531 from Cohesion Biosciences
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SKA2 miRNA 3'UTR clone - MiUTR1H-03435 from Creative biogene
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