| Gene Symbol |
BATF2
|
| Entrez Gene |
116071
|
| Alt Symbol |
SARI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
basic leucine zipper transcription factor, ATF-like 2
|
| Other Description |
B-ATF-2|basic leucine zipper transcriptional factor ATF-like 2|suppressor of AP-1 regulated by IFN
|
| Swissprots |
D9IC56 Q8N1L9 Q96EH4 Q8NAF4 Q8NAL8
|
| Accessions |
EAW74330 EAW74331 Q8N1L9 AK092453 BAC03894 AK096702 BAC04846 AK300917 BAG62549 BC011931 BC012330 AAH12330 BP206576 HM134154 ADJ55304 XM_011544750 XP_011543052 NM_001300807 NP_001287736 NM_001300808 NP_001287737 NM_138456 NP_612465
|
| Function |
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter. {ECO:0000250, ECO:0000269|PubMed:20531301}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}.
|