Gene Symbol | BATF2 |
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Entrez Gene | 116071 |
Alt Symbol | SARI |
Species | Human |
Gene Type | protein-coding |
Description | basic leucine zipper transcription factor, ATF-like 2 |
Other Description | B-ATF-2|basic leucine zipper transcriptional factor ATF-like 2|suppressor of AP-1 regulated by IFN |
Swissprots | D9IC56 Q8N1L9 Q96EH4 Q8NAF4 Q8NAL8 |
Accessions | EAW74330 EAW74331 Q8N1L9 AK092453 BAC03894 AK096702 BAC04846 AK300917 BAG62549 BC011931 BC012330 AAH12330 BP206576 HM134154 ADJ55304 XM_011544750 XP_011543052 NM_001300807 NP_001287736 NM_001300808 NP_001287737 NM_138456 NP_612465 |
Function | AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter. {ECO:0000250, ECO:0000269|PubMed:20531301}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}. |
BATF2 CRISPR/Cas9 KO Plasmid (h) - sc-403270 from Santa Cruz Biotechnology
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BATF2 HDR Plasmid (h) - sc-403270-HDR from Santa Cruz Biotechnology
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BATF2 Double Nickase Plasmid (h) - sc-403270-NIC from Santa Cruz Biotechnology
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BATF2 Double Nickase Plasmid (h2) - sc-403270-NIC-2 from Santa Cruz Biotechnology
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BATF2 CRISPR Activation Plasmid (h) - sc-403270-ACT from Santa Cruz Biotechnology
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BATF2 CRISPR Activation Plasmid (h2) - sc-403270-ACT-2 from Santa Cruz Biotechnology
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BATF2 Lentiviral Activation Particles (h) - sc-403270-LAC from Santa Cruz Biotechnology
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BATF2 Lentiviral Activation Particles (h2) - sc-403270-LAC-2 from Santa Cruz Biotechnology
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BATF2 siRNA (h) - sc-97016 from Santa Cruz Biotechnology
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BATF2 shRNA Plasmid (h) - sc-97016-SH from Santa Cruz Biotechnology
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BATF2 shRNA (h) Lentiviral Particles - sc-97016-V from Santa Cruz Biotechnology
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MGC20410 RNAi - H00116071-R01 from Novus Biologicals
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MISSION® esiRNA - EHU041281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3870 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3870 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08478 from Sigma-Aldrich
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BATF2 siRNA (Human) - CRJ4482 from Cohesion Biosciences
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BATF2 - MBS8222038 from MyBioSource
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BATF2 CRISPR/Cas9 KO Plasmid (h2) - sc-403270-KO-2 from Santa Cruz Biotechnology
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BATF2 HDR Plasmid (h2) - sc-403270-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human BATF2 (NM_138456.3) - SHH244986 from Creative biogene
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shRNA set against Human BATF2(NM_138456.3) - SHG091567 from Creative biogene
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Human BATF2 siRNA - orb274983 from Biorbyt
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BATF2 shRNA Plasmid (Human) - CHJ4482 from Cohesion Biosciences
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BATF2 miRNA 3'UTR clone - MiUTR1H-00813 from Creative biogene
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