GEMIN5

Gene Symbol	GEMIN5
Entrez Gene	25929
Alt Symbol	GEMIN-5
Species	Human
Gene Type	protein-coding
Description	gem (nuclear organelle) associated protein 5
Other Description	gem-associated protein 5
Swissprots	Q8TEQ6 Q9H9K3 Q8WWV4 Q14CV0 Q9UFI5 Q969W4
Accessions	CCQ43511 EAW61623 EAW61624 Q8TEQ6 AK022748 BAB14222 AK074066 BAB84892 AK315101 AL117665 CAB56035 AY063750 AAL38980 BC008776 AAH08776 BC014147 AAH14147 BC036894 AAH36894 BC040931 BC113614 AAI13615 BC143724 AAI43725 BX329222 DA328736 DA400244 NM_001252156 NP_001239085 NM_015465 NP_056280
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex. {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161}.
Subcellular Location	Nucleus, nucleoplasm {ECO:0000269|PubMed:11714716}. Nucleus, gem {ECO:0000269|PubMed:11714716}. Cytoplasm {ECO:0000269|PubMed:11714716}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Gemin5 (10G11) - sc-136200 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Gemin5 (C-19) - sc-21440 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Gemin 5 antibody - ab31689 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Gemin 5 antibody - ab99360 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-GEMIN5 Antibody (aa1360-1410) - LS-C288135 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-GEMIN5 Antibody (aa1410-1438) - LS-C288136 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 5 Antibody - NB100-61049 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 5 Antibody - NBP1-90354 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 5 Antibody - NB100-61048 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody - bs-13329R from Bioss Prices $245.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13329R-A350 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13329R-A488 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13329R-A555 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13329R-A647 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody, Cy3 Conjugated - bs-13329R-Cy3 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody, Cy5 Conjugated - bs-13329R-Cy5 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody, Cy5.5 Conjugated - bs-13329R-Cy5.5 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody, Cy7 Conjugated - bs-13329R-Cy7 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody, FITC Conjugated - bs-13329R-FITC from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody, Biotin Conjugated - bs-13329R-Biotin from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Gemin 5 Polyclonal Antibody, HRP Conjugated - bs-13329R-HRP from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-GEMIN5 antibody produced in rabbit - HPA037393 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin-5 antibody - 24897-1-AP from Acris Antibodies Prices $270.00 Sizes 150 µl Host Rabbit Clonality Polyclonal

GEMIN5 antibody - 24897-1-AP from Proteintech Group Prices $279.00 Sizes con: 73 μg/150μl Host Rabbit Clonality Polyclonal

Anti-GEMIN5 (aa 1-100) polyclonal antibody - CPBT-35418RH from Creative Diagnostics Host Rabbit Clonality Polyclonal

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