GEMIN5

Gene Symbol GEMIN5
Entrez Gene 25929
Alt Symbol GEMIN-5
Species Human
Gene Type protein-coding
Description gem (nuclear organelle) associated protein 5
Other Description gem-associated protein 5
Swissprots Q8TEQ6 Q9H9K3 Q8WWV4 Q14CV0 Q9UFI5 Q969W4
Accessions CCQ43511 EAW61623 EAW61624 Q8TEQ6 AK022748 BAB14222 AK074066 BAB84892 AK315101 AL117665 CAB56035 AY063750 AAL38980 BC008776 AAH08776 BC014147 AAH14147 BC036894 AAH36894 BC040931 BC113614 AAI13615 BC143724 AAI43725 BX329222 DA328736 DA400244 NM_001252156 NP_001239085 NM_015465 NP_056280
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex. {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:11714716}. Nucleus, gem {ECO:0000269|PubMed:11714716}. Cytoplasm {ECO:0000269|PubMed:11714716}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Top Pathways RNA transport

Gemin5 CRISPR/Cas9 KO Plasmid (h) - sc-416368 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gemin5 HDR Plasmid (h) - sc-416368-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gemin5 Double Nickase Plasmid (h) - sc-416368-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gemin5 Double Nickase Plasmid (h2) - sc-416368-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gemin5 CRISPR Activation Plasmid (h) - sc-416368-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gemin5 CRISPR Activation Plasmid (h2) - sc-416368-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gemin5 Lentiviral Activation Particles (h) - sc-416368-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gemin5 Lentiviral Activation Particles (h2) - sc-416368-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gemin5 siRNA (h) - sc-42131 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Gemin5 shRNA Plasmid (h) - sc-42131-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Gemin5 shRNA (h) Lentiviral Particles - sc-42131-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU049241 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9230 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9230 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GEMIN5 siRNA (Human) - CRH8596 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GEMIN5 - MBS8221828 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GEMIN5 (NM_015465.4) - SHH300478 from Creative biogene

Category siRNA
Species Reactivities Human

Human GEMIN5 siRNA - orb269098 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GEMIN5 shRNA Plasmid (Human) - CHH8596 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GEMIN5 miRNA 3'UTR clone - MiUTR3H-08897 from Creative biogene

Species Reactivities Human
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