GEMIN5

Gene Symbol	GEMIN5
Entrez Gene	25929
Alt Symbol	GEMIN-5
Species	Human
Gene Type	protein-coding
Description	gem (nuclear organelle) associated protein 5
Other Description	gem-associated protein 5
Swissprots	Q8TEQ6 Q9H9K3 Q8WWV4 Q14CV0 Q9UFI5 Q969W4
Accessions	CCQ43511 EAW61623 EAW61624 Q8TEQ6 AK022748 BAB14222 AK074066 BAB84892 AK315101 AL117665 CAB56035 AY063750 AAL38980 BC008776 AAH08776 BC014147 AAH14147 BC036894 AAH36894 BC040931 BC113614 AAI13615 BC143724 AAI43725 BX329222 DA328736 DA400244 NM_001252156 NP_001239085 NM_015465 NP_056280
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex. {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161}.
Subcellular Location	Nucleus, nucleoplasm {ECO:0000269|PubMed:11714716}. Nucleus, gem {ECO:0000269|PubMed:11714716}. Cytoplasm {ECO:0000269|PubMed:11714716}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Gemin 5 peptide - ab32714 from Abcam Category Peptide

Human Gemin 5 protein fragment - ab161837 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human Gemin 5 Protein - H00025929-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Gemin-5 - H00025929-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Gemin-5 - H00025929-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

GEMIN5 fusion protein - ag19268 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

GEMIN5 fusion protein - ag19220 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Gem-associated protein 5(GEMIN5) ,partial - CSB-YP844733HU CSB-EP844733HU CSB-BP844733HU CSB-MP844733HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Gemin-5 - TP317516 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Gemin 5 Recombinant Protein Antigen - NBP1-90354PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

GEMIN5 Peptide, Human - M34GP06206H from Creative Peptides Category Peptide Source Synthetic. Species Human

Gem-associated protein 5 (GEMIN5), partial, Recombinant Protein - MBS1313907 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Gemin 5 Recombinant Protein Antigen - NBP2-58136PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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