| Gene Symbol | GEMIN5 |
|---|---|
| Entrez Gene | 25929 |
| Alt Symbol | GEMIN-5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | gem (nuclear organelle) associated protein 5 |
| Other Description | gem-associated protein 5 |
| Swissprots | Q8TEQ6 Q9H9K3 Q8WWV4 Q14CV0 Q9UFI5 Q969W4 |
| Accessions | CCQ43511 EAW61623 EAW61624 Q8TEQ6 AK022748 BAB14222 AK074066 BAB84892 AK315101 AL117665 CAB56035 AY063750 AAL38980 BC008776 AAH08776 BC014147 AAH14147 BC036894 AAH36894 BC040931 BC113614 AAI13615 BC143724 AAI43725 BX329222 DA328736 DA400244 NM_001252156 NP_001239085 NM_015465 NP_056280 |
| Function | The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex. {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161}. |
| Subcellular Location | Nucleus, nucleoplasm {ECO:0000269|PubMed:11714716}. Nucleus, gem {ECO:0000269|PubMed:11714716}. Cytoplasm {ECO:0000269|PubMed:11714716}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm. |
| Top Pathways | RNA transport |
GEMIN5 - MBS1272031 from MyBioSource
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Human GEMIN5 ORF Clone (BC113614) - CDCS409964 from Creative biogene
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