| Gene Symbol |
PLEKHF1
|
| Entrez Gene |
79156
|
| Alt Symbol |
APPD, LAPF, PHAFIN1, ZFYVE15
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleckstrin homology domain containing, family F (with FYVE domain) member 1
|
| Other Description |
PH and FYVE domain-containing protein 1|PH domain-containing family F member 1|apoptosis-inducing protein D|lysosome-associated apoptosis-inducing protein containing PH and FYVE domains|phafin 1|phafin-1|pleckstrin homology domain-containing family F member 1|zinc finger FYVE domain-containing protein 15
|
| Swissprots |
Q9BUB9 Q96S99 Q96K11
|
| Accessions |
Q96S99 AF434818 AAL30773 AK027758 BAB55349 AK225814 AK301616 BAG63101 AY037145 AAK67626 BC002744 AAH02744 BC018876 XM_005259256 XP_005259313 XM_006723378 XP_006723441 XM_011527309 XP_011525611 NM_024310 NP_077286
|
| Function |
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. {ECO:0000269|PubMed:16188880}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16188880}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16188880}. Lysosome {ECO:0000269|PubMed:16188880}. Note=Translocates to lysosome during apoptosis.
|
| Tissue Specificity |
Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung. {ECO:0000269|PubMed:16188880}.
|
![Western Blot: APPD Overexpression Lysate (Adult Normal) [NBL1-14508] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for APPD.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7220_APPD%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14508-img0002.jpg)