PLEKHF1

Gene Symbol PLEKHF1
Entrez Gene 79156
Alt Symbol APPD, LAPF, PHAFIN1, ZFYVE15
Species Human
Gene Type protein-coding
Description pleckstrin homology domain containing, family F (with FYVE domain) member 1
Other Description PH and FYVE domain-containing protein 1|PH domain-containing family F member 1|apoptosis-inducing protein D|lysosome-associated apoptosis-inducing protein containing PH and FYVE domains|phafin 1|phafin-1|pleckstrin homology domain-containing family F member 1|zinc finger FYVE domain-containing protein 15
Swissprots Q9BUB9 Q96S99 Q96K11
Accessions Q96S99 AF434818 AAL30773 AK027758 BAB55349 AK225814 AK301616 BAG63101 AY037145 AAK67626 BC002744 AAH02744 BC018876 XM_005259256 XP_005259313 XM_006723378 XP_006723441 XM_011527309 XP_011525611 NM_024310 NP_077286
Function May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. {ECO:0000269|PubMed:16188880}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16188880}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16188880}. Lysosome {ECO:0000269|PubMed:16188880}. Note=Translocates to lysosome during apoptosis.
Tissue Specificity Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung. {ECO:0000269|PubMed:16188880}.

PLEKHF1 (C-19) - sc-243821 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PLEKHF1 (N-15) - sc-243819 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-APPD antibody - ab10081 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-APPD antibody - Aminoterminal end - ab56097 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLEKHF1 Antibody (C-Terminus) - LS-C30684 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLEKHF1 Antibody (N-Terminus) - LS-C47040 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PLEKHF1 Antibody (aa51-79, AP) - LS-C266529 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHF1 Antibody (aa51-79, APC) - LS-C266531 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHF1 Antibody (aa51-79, Biotin) - LS-C266532 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHF1 Antibody (aa51-79, FITC) - LS-C266533 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHF1 Antibody (aa51-79, Azide-free, HRP) - LS-C266534 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHF1 Antibody (aa51-79, PE) - LS-C266535 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHF1 Antibody (aa50-79) - LS-C324101 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLEKHF1 Antibody (aa51-79) - LS-C163787 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PLEKHF1 Antibody western blot of 293 cell line lysates (35 ug/lane). The PLEKHF1 antibody detected the PLEKHF1 protein (arrow).

APPD Antibody - NBP1-90124 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: APPD Antibody [NBP1-90124] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10Lane 2: Negative control (vector only transfected HEK293T lysate)Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY402983)

APPD Antibody - NBP1-79945 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

APPD Polyclonal Antibody - bs-6793R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat lung labeled with Anti-APPD/LAPF Polyclonal Antibody, Unconjugated (bs-6793R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

ANTI-PLEKHF1(N-TERMINAL) antibody produced in rabbit - SAB1305135 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PLEKHF1 (N-term): <B>Cat. No. SAB1305135</B>: PLEKHF1 Antibody (N-term) western blot analysis in 293 cell line lysates (35 μg/lane).

Anti-PLEKHF1 antibody produced in rabbit - HPA025925 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PLEKHF1: <B>Cat. No. HPA025925</B>: Immunohistochemical staining of human hippocampus shows strong cytoplasmic positivity in astrocyte-like cells.

Anti-APPD antibody produced in rabbit - AV09055 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

APPD antibody - C-terminal region (AVARP09055_T100) - AVARP09055_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PLEKHF1-Antibody-N-term - AP16531a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PLEKHF1 Antibody (N-term) at 1:1000 dilution + human heart lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 31 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

APPD antibody - GTX77739 from GeneTex

Prices $289.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

PLEKHF1 Antibody - N-terminal region (OAAB11949) - OAAB11949 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PLEKHF1 Polyclonal Antibody - A3493 from ABclonal

Prices $200.00, $480.00
Sizes 50 µg, 200 µg
Host Rabbit
Clonality Polyclonal
Search more