PLEKHF1

Gene Symbol	PLEKHF1
Entrez Gene	79156
Alt Symbol	APPD, LAPF, PHAFIN1, ZFYVE15
Species	Human
Gene Type	protein-coding
Description	pleckstrin homology domain containing, family F (with FYVE domain) member 1
Other Description	PH and FYVE domain-containing protein 1|PH domain-containing family F member 1|apoptosis-inducing protein D|lysosome-associated apoptosis-inducing protein containing PH and FYVE domains|phafin 1|phafin-1|pleckstrin homology domain-containing family F member 1|zinc finger FYVE domain-containing protein 15
Swissprots	Q9BUB9 Q96S99 Q96K11
Accessions	Q96S99 AF434818 AAL30773 AK027758 BAB55349 AK225814 AK301616 BAG63101 AY037145 AAK67626 BC002744 AAH02744 BC018876 XM_005259256 XP_005259313 XM_006723378 XP_006723441 XM_011527309 XP_011525611 NM_024310 NP_077286
Function	May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. {ECO:0000269|PubMed:16188880}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16188880}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16188880}. Lysosome {ECO:0000269|PubMed:16188880}. Note=Translocates to lysosome during apoptosis.
Tissue Specificity	Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung. {ECO:0000269|PubMed:16188880}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PLEKHF1 Antibody Blocking Peptide - LS-E4256 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLEKHF1 Antibody Blocking Peptide - LS-E10628 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLEKHF1-Antibody-N-term-Blocking-Peptide - BP16531a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APPD Blocking Peptide - 33R-7671 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PLEKHF1 fusion protein - ag14228 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PLEKHF1 fusion protein - Ag16949 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human PLEKHF1, GST-tagged - PLEKHF1-1782H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Pleckstrin homology domain-containing family F member 1(PLEKHF1) - CSB-YP842759HU CSB-EP842759HU CSB-BP842759HU CSB-MP842759HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PLEKHF1 - TP301282 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Pleckstrin homology domain-containing family F member 1 (PLEKHF1), Recombinant Protein - MBS1409639 from MyBioSource Category Protein Prices $1,035.00, $1,035.00, $1,265.00, $1,265.00, $1,600.00, $1,600.00, $2,065.00, $2,065.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

APPD Recombinant Protein Antigen - NBP1-90124PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PLEKHF1 Peptide, Human - M34GP11932H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human PLEKHF1 Protein (1-279 aa), His-Myc-tagged - PLEKHF1-2768H from Creative Biomart Category Protein Source Baculovirus Species Human

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