PLEKHF1

Gene Symbol PLEKHF1
Entrez Gene 79156
Alt Symbol APPD, LAPF, PHAFIN1, ZFYVE15
Species Human
Gene Type protein-coding
Description pleckstrin homology domain containing, family F (with FYVE domain) member 1
Other Description PH and FYVE domain-containing protein 1|PH domain-containing family F member 1|apoptosis-inducing protein D|lysosome-associated apoptosis-inducing protein containing PH and FYVE domains|phafin 1|phafin-1|pleckstrin homology domain-containing family F member 1|zinc finger FYVE domain-containing protein 15
Swissprots Q9BUB9 Q96S99 Q96K11
Accessions Q96S99 AF434818 AAL30773 AK027758 BAB55349 AK225814 AK301616 BAG63101 AY037145 AAK67626 BC002744 AAH02744 BC018876 XM_005259256 XP_005259313 XM_006723378 XP_006723441 XM_011527309 XP_011525611 NM_024310 NP_077286
Function May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. {ECO:0000269|PubMed:16188880}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16188880}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16188880}. Lysosome {ECO:0000269|PubMed:16188880}. Note=Translocates to lysosome during apoptosis.
Tissue Specificity Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung. {ECO:0000269|PubMed:16188880}.

PLEKHF1 CRISPR/Cas9 KO Plasmid (h) - sc-410617 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF1 HDR Plasmid (h) - sc-410617-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF1 Double Nickase Plasmid (h) - sc-410617-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF1 Double Nickase Plasmid (h2) - sc-410617-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF1 CRISPR Activation Plasmid (h) - sc-410617-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF1 CRISPR Activation Plasmid (h2) - sc-410617-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF1 Lentiviral Activation Particles (h) - sc-410617-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF1 Lentiviral Activation Particles (h2) - sc-410617-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PLEKHF1 siRNA (h) - sc-97887 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLEKHF1 shRNA Plasmid (h) - sc-97887-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PLEKHF1 shRNA (h) Lentiviral Particles - sc-97887-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APPD RNAi - H00079156-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU122361 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16957 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16957 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06856 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06856

PLEKHF1 siRNA (Human) - CRJ2335 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PLEKHF1 (NM_024310.4) - SHH377580 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PLEKHF1(NM_024310.4) - SHR121962 from Creative biogene

Category siRNA
Species Reactivities Human

Human PLEKHF1 siRNA - orb272836 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PLEKHF1 shRNA Plasmid (Human) - CHJ2335 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PLEKHF1 miRNA 3'UTR clone - MiUTR1H-07998 from Creative biogene

Species Reactivities Human
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