DLC1

Gene Symbol	DLC1
Entrez Gene	10395
Alt Symbol	ARHGAP7, HP, STARD12, p122-RhoGAP
Species	Human
Gene Type	protein-coding
Description	DLC1 Rho GTPase activating protein
Other Description	Rho-GTPase-activating protein 7|START domain-containing protein 12|StAR-related lipid transfer (START) domain containing 12|deleted in liver cancer 1 protein|deleted in liver cancer 1 variant 2|rho GTPase-activating protein 7|rho-type GTPase-activating protein 7
Swissprots	Q9H7A2 O14868 Q9C0E0 E9PGY9 B8PTI0 Q7Z5R8 B4DR10 Q96QB1 E9PF76 Q86UC6 E9PDZ8 O43199
Accessions	AAK97501 EAW63851 EAW63852 EAW63853 EAW63854 EAW63855 Q96QB1 AB051510 BAB21814 AF026219 AAB81637 AF035119 AAB87700 AK023128 AK024773 BAB14996 AK025544 AK025733 AK225098 AK289734 BAF82423 AK291682 BAF84371 AK299049 BAG61122 AL117604 BC049842 AAH49842 BC054511 AAH54511 BC095415 BP284911 CB961755 DA549448 DQ092382 AAZ32940 DQ092383 AAZ32941 DQ092384 AAZ32942 EU832131 ACE87481 EU832224 ACE86794 XM_005273374 XP_005273431 XM_005273375 XP_005273432 NM_001164271 NP_001157743 NM_006094 NP_006085 NM_024767 NP_079043 NM_182643 NP_872584
Function	Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422}.
Subcellular Location	Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery.
Tissue Specificity	Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DLC1-Over-expression-Lysate - LY15997a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

DLC1 293T Cell Transient Overexpression Lysate(Denatured) - H00010395-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

DLC1 overexpression lysate - LY401837 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

DLC1 293 Cell Lysate - 401637 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg Tissue Liver Disease Cancer

DLC1 Overexpression Lysate (Denatured) - H00010395-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

DLC1 Overexpression Lysate (Native) - NBL1-09907 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

DLC-1 (h): 293T Lysate - sc-116333 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

DLC1 Over-expression Lysate Product - GWB-9F0C37 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

DLC1 Overexpression Lysate (Native) - NBP2-04827 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DLC1 Overexpression Lysate (Native) - NBP2-10056 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

DLC1 Overexpression Lysate (Denatured) - H00010395-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human DLC1 Knockdown Stable Cell Line - CSC-DC004333 from Creative biogene Category Cell Line Species Human

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