DLC1

Gene Symbol DLC1
Entrez Gene 10395
Alt Symbol ARHGAP7, HP, STARD12, p122-RhoGAP
Species Human
Gene Type protein-coding
Description DLC1 Rho GTPase activating protein
Other Description Rho-GTPase-activating protein 7|START domain-containing protein 12|StAR-related lipid transfer (START) domain containing 12|deleted in liver cancer 1 protein|deleted in liver cancer 1 variant 2|rho GTPase-activating protein 7|rho-type GTPase-activating protein 7
Swissprots Q9H7A2 O14868 Q9C0E0 E9PGY9 B8PTI0 Q7Z5R8 B4DR10 Q96QB1 E9PF76 Q86UC6 E9PDZ8 O43199
Accessions AAK97501 EAW63851 EAW63852 EAW63853 EAW63854 EAW63855 Q96QB1 AB051510 BAB21814 AF026219 AAB81637 AF035119 AAB87700 AK023128 AK024773 BAB14996 AK025544 AK025733 AK225098 AK289734 BAF82423 AK291682 BAF84371 AK299049 BAG61122 AL117604 BC049842 AAH49842 BC054511 AAH54511 BC095415 BP284911 CB961755 DA549448 DQ092382 AAZ32940 DQ092383 AAZ32941 DQ092384 AAZ32942 EU832131 ACE87481 EU832224 ACE86794 XM_005273374 XP_005273431 XM_005273375 XP_005273432 NM_001164271 NP_001157743 NM_006094 NP_006085 NM_024767 NP_079043 NM_182643 NP_872584
Function Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422}.
Subcellular Location Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery.
Tissue Specificity Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.

DLC-1 (C-12) - sc-271915 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DLC-1 (C-12): sc-271915. Western blot analysis of DLC-1 expression in MCF7 (A), ES-2 (B), SK-BR-3 (C) and KNRK (D) whole cell lysates.

DLC-1 (H-260) - sc-32931 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DLC-1 (H-260): sc-32931. Western blot analysis of DLC-1 expression in c4 whole cell lysate.

DLC-1 (C-14) - sc-28434 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DLC-1 (C-14): sc-28434. Western blot analysis of DLC-1 expression in non-transfected: sc-117752 (A) and human DLC-1 transfected: sc-116333 (B) 293T whole cell lysates.

Anti-DLC1 (phospho S567) antibody - ab93381 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DLC1 antibody - ab21200 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab21200 (5 µg/ml) staining DLC1 in Human Adrenal Gland by IHC-P.  Steamed antigen retrieval in citrate buffer pH6, AP-staining.  This image shows strong reticulate staining in the cytoplasm of medular cells.

Anti-DLC1 antibody - ab196937 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of A549 cells labeling DLC1 with ab196937 at 1/100 dilution. The image on the right is treated with the synthesized peptide.

Anti-DLC1 antibody - ab126257 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-DLC1 antibody (ab126257) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-DLC1 antibody - C-terminal - ab180697 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DLC1 antibody - C-terminal (ab180697) at 1/500 dilution + Mouse lung extract

DLC1 (Isoform 1 and 3) Antibody - NB300-917 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

DLC1 Antibody - NBP2-16173 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DLC1 Antibody [NBP2-16173] - A: HepG2.

DLC1 Antibody - H00010395-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

DLC1 Antibody - H00010395-B01-50ul from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

DLC1 Antibody - H00010395-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DLC1 antibody produced in rabbit - SAB4200351 from Sigma-Aldrich

Prices $342.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B> <BR/>Cytoplasmic and perinuclear localization of DLC1 in HEK293-T cells overexpressing human DLC1. Fixed cells were stained with 1 μg/mL Anti-DLC1 (<B>Cat. No. SAB4200351</B>) followed by Goat Anti-Rabbit IgG, Cy3 conjugate (×40 magnification). Nuclear staining with DAPI.

Anti-DLC1 antibody produced in rabbit - AV52138 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: 721_B (<B>Cat. No. AV52138</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.5 μg/mL in cell type 721_B

Anti-DLC1 (C-terminal region) antibody produced in rabbit - SAB4200490 from Sigma-Aldrich

Prices $337.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Localization of DLC1 in human colon. Formalin-fixed paraffin-embedded tissue was stained with 10 μg/mL. Anti-DLC1 (C-terminal region) (<B>Cat. No. SAB4200490</B>) followed by Biotin-Goat Anti-Rabbit IgG/ExtrAvidin<SUP>®</SUP>HRP (×20 magnification).

Anti-DLC1 (IsoformS 1 and 3) antibody produced in goat - SAB2500318 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DLC1 (Isoforms 1 and 3): <B>Cat. No. SAB2500318</B>: (5 μg/mL) staining of paraffin embedded Human Adrenal Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-DLC1 antibody produced in rabbit - HPA017753 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DLC1: <B>Cat. No. HPA017753</B>: Immunohistochemical staining of human duodenum shows distinct positivity of microvilli in glandular cells.

Anti-RHG07, N-Terminal antibody produced in rabbit - SAB4500089 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RHG07, N-Terminal: <B>Cat. No. SAB4500089</B>: Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue using Anti-RHG07, N-Terminal antibody. Cells on the left were treated with the Anti-RHG07, N-Terminal antibody. Cells on the right (negative control) were treated with both Anti-RHG07, N-Terminal antibody and the synthesized immunogen peptide.

DLC1 antibody - C-terminal region (ARP52138_P050) - ARP52138_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DLC1-Isoforms-1-and-3-Antibody - AF1327a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF1327a (5 µg/ml) staining of paraffin embedded Human Adrenal Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

DLC1 (Isoforms 1 and 3) antibody, N-term - GTX89689 from GeneTex

Prices $319.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-DLC1 (Isoforms 1 and 3) antibody, N-term used in IHC (Formalin-fixed paraffin-embedded sections). GTX89689

DLC1 Antibody (OAAF02629) - OAAF02629 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

DLC1 Antibody (OAEB00885) - OAEB00885 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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