| Gene Symbol |
DLC1
|
| Entrez Gene |
10395
|
| Alt Symbol |
ARHGAP7, HP, STARD12, p122-RhoGAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DLC1 Rho GTPase activating protein
|
| Other Description |
Rho-GTPase-activating protein 7|START domain-containing protein 12|StAR-related lipid transfer (START) domain containing 12|deleted in liver cancer 1 protein|deleted in liver cancer 1 variant 2|rho GTPase-activating protein 7|rho-type GTPase-activating protein 7
|
| Swissprots |
Q9H7A2 O14868 Q9C0E0 E9PGY9 B8PTI0 Q7Z5R8 B4DR10 Q96QB1 E9PF76 Q86UC6 E9PDZ8 O43199
|
| Accessions |
AAK97501 EAW63851 EAW63852 EAW63853 EAW63854 EAW63855 Q96QB1 AB051510 BAB21814 AF026219 AAB81637 AF035119 AAB87700 AK023128 AK024773 BAB14996 AK025544 AK025733 AK225098 AK289734 BAF82423 AK291682 BAF84371 AK299049 BAG61122 AL117604 BC049842 AAH49842 BC054511 AAH54511 BC095415 BP284911 CB961755 DA549448 DQ092382 AAZ32940 DQ092383 AAZ32941 DQ092384 AAZ32942 EU832131 ACE87481 EU832224 ACE86794 XM_005273374 XP_005273431 XM_005273375 XP_005273432 NM_001164271 NP_001157743 NM_006094 NP_006085 NM_024767 NP_079043 NM_182643 NP_872584
|
| Function |
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422}.
|
| Subcellular Location |
Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery.
|
| Tissue Specificity |
Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.
|