Gene Symbol | RDH11 |
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Entrez Gene | 51109 |
Alt Symbol | ARSDR1, CGI82, HCBP12, MDT1, PSDR1, RALR1, RDJCSS, SCALD, SDR7C1 |
Species | Human |
Gene Type | protein-coding |
Description | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) |
Other Description | HCV core-binding protein HCBP12|androgen-regulated short-chain dehydrogenase/reductase 1|prostate short-chain dehydrogenase reductase 1|prostate short-chain dehydrogenase/reductase 1|retinal reductase 1|retinol dehydrogenase 11|short chain dehydrogenase/reductase family 7C member 1|short chain dehydrogenase/reductase family 7C, member 1 |
Swissprots | Q0QD40 Q9Y391 Q6IAH5 B4DDW0 A6NDK3 A8K062 B2RB26 Q8TC12 Q9NRW0 |
Accessions | CAF86792 EAW80948 EAW80949 EAW80950 Q8TC12 AB209223 BAD92460 AF151840 AAD34077 AF167438 AAF89632 AF395068 AAK72049 AI382141 AK057195 BAG51881 AK074749 BAG51997 AK289427 BAF82116 AK293355 BAG56871 AK307500 AK314465 BAG37073 BC000112 AAH00112 BC011727 AAH11727 BC026274 AAH26274 BC037302 AAH37302 BC051291 AAH51291 CR457180 CAG33461 DC355364 DQ426886 ABD90542 HQ447163 ADQ31650 NM_001252650 NP_001239579 NM_016026 NP_057110 |
Function | Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12036956}; Single-pass type II membrane protein {ECO:0000269|PubMed:12036956}. |
Tissue Specificity | Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes. |
Top Pathways | Retinol metabolism |
Human RDH11 full length protein - ab162417 from Abcam
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RDH11 Antibody Blocking Peptide - LS-E17490 from LifeSpan Bioscience
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RDH11 Recombinant Protein - H00051109-P01 from Novus Biologicals
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Human RDH11 protein - orb244488 from Biorbyt
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RDH11 Blocking Peptide - 33R-8425 from Fitzgerald
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RDH11 - H00051109-P01-10 from Acris Antibodies
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RDH11 - H00051109-P01-25 from Acris Antibodies
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RDH11 fusion protein - ag1485 from Proteintech Group
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Recombinant human Retinol dehydrogenase 11 - CSB-YP019523HU CSB-BP019523HU CSB-MP019523HU from Cusabio
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Recombinant human Retinol dehydrogenase 11 - CSB-EP019523HU from Cusabio
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Recombinant Human Retinol dehydrogenase 11(RDH11) - CSB-YP844716HU CSB-EP844716HU CSB-BP844716HU CSB-MP844716HU from Cusabio
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RDH11 - TP305003 from Acris Antibodies
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PSDR1-Antibody-N-term-Blocking-Peptide - BP6666a from Abgent, a WuXi AppTec company
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RDH11 Peptide, Human - M34GP13129H from Creative Peptides
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RDH11 Recombinant Protein (OPCA01819) - OPCA01819 from Aviva Systems Biology
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RDH11 Antibody - SH-A15170 from Novatein Biosciences
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Recombinant human Retinol dehydrogenase 11 - AP70705 from Signalway Antibody
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Retinol dehydrogenase 11, Recombinant Protein - MBS9420605 from MyBioSource
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Retinol dehydrogenase 11, Recombinant Protein - MBS969601 from MyBioSource
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Retinol dehydrogenase 11 (RDH11), Recombinant Protein - MBS1333399 from MyBioSource
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Recombinant Human RDH11 Protein (22-318 aa), His-SUMO-tagged - RDH11-769H from Creative Biomart
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