| Gene Symbol |
ITGAX
|
| Entrez Gene |
3687
|
| Alt Symbol |
CD11C, SLEB6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin, alpha X (complement component 3 receptor 4 subunit)
|
| Other Description |
CD11 antigen-like family member C|integrin alpha-X|integrin, alpha X (antigen CD11C (p150), alpha polypeptide)|leu M5, alpha subunit|leukocyte adhesion glycoprotein p150,95 alpha chain|leukocyte adhesion receptor p150,95|leukocyte surface antigen p150,95, alpha subunit|myeloid membrane antigen, alpha subunit|p150 95 integrin alpha chain
|
| Swissprots |
Q8IVA6 P20702
|
| Accessions |
AAA35661 AAA51620 EAW52140 EAW52141 EAW52142 P20702 AK074047 BAB84873 AK293367 BAG56881 AK296666 BAG59263 AK309642 AW014280 BC037577 BC038237 AAH38237 BM149283 CA308944 DA324567 DQ892486 ABM83412 DQ895697 ABM86623 M81695 AAA59180 XM_011545852 XP_011544154 XM_011545853 XP_011544155 XM_011545854 XP_011544156 XR_950797 NM_000887 NP_000878 NM_001286375 NP_001273304
|
| Function |
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Predominantly expressed in monocytes and granulocytes.
|
| Top Pathways |
Tuberculosis, Regulation of actin cytoskeleton
|