Gene Symbol | ITGAX |
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Entrez Gene | 3687 |
Alt Symbol | CD11C, SLEB6 |
Species | Human |
Gene Type | protein-coding |
Description | integrin, alpha X (complement component 3 receptor 4 subunit) |
Other Description | CD11 antigen-like family member C|integrin alpha-X|integrin, alpha X (antigen CD11C (p150), alpha polypeptide)|leu M5, alpha subunit|leukocyte adhesion glycoprotein p150,95 alpha chain|leukocyte adhesion receptor p150,95|leukocyte surface antigen p150,95, alpha subunit|myeloid membrane antigen, alpha subunit|p150 95 integrin alpha chain |
Swissprots | Q8IVA6 P20702 |
Accessions | AAA35661 AAA51620 EAW52140 EAW52141 EAW52142 P20702 AK074047 BAB84873 AK293367 BAG56881 AK296666 BAG59263 AK309642 AW014280 BC037577 BC038237 AAH38237 BM149283 CA308944 DA324567 DQ892486 ABM83412 DQ895697 ABM86623 M81695 AAA59180 XM_011545852 XP_011544154 XM_011545853 XP_011544155 XM_011545854 XP_011544156 XR_950797 NM_000887 NP_000878 NM_001286375 NP_001273304 |
Function | Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Predominantly expressed in monocytes and granulocytes. |
Top Pathways | Tuberculosis, Regulation of actin cytoskeleton |
Integrin αX CRISPR/Cas9 KO Plasmid (h) - sc-401765 from Santa Cruz Biotechnology
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Integrin αX HDR Plasmid (h) - sc-401765-HDR from Santa Cruz Biotechnology
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Integrin αX Double Nickase Plasmid (h) - sc-401765-NIC from Santa Cruz Biotechnology
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Integrin αX Double Nickase Plasmid (h2) - sc-401765-NIC-2 from Santa Cruz Biotechnology
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Integrin αX CRISPR Activation Plasmid (h) - sc-401765-ACT from Santa Cruz Biotechnology
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Integrin αX CRISPR Activation Plasmid (h2) - sc-401765-ACT-2 from Santa Cruz Biotechnology
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Integrin αX Lentiviral Activation Particles (h) - sc-401765-LAC from Santa Cruz Biotechnology
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Integrin αX Lentiviral Activation Particles (h2) - sc-401765-LAC-2 from Santa Cruz Biotechnology
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Integrin αX siRNA (h) - sc-35695 from Santa Cruz Biotechnology
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Integrin αX shRNA Plasmid (h) - sc-35695-SH from Santa Cruz Biotechnology
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Integrin αX shRNA (h) Lentiviral Particles - sc-35695-V from Santa Cruz Biotechnology
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CD11c RNAi - H00003687-R02 from Novus Biologicals
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MISSION® esiRNA - EHU072691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1834 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1834 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08373 from Sigma-Aldrich
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ITGAX siRNA (Human) - CRH2476 from Cohesion Biosciences
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ITGAX - MBS8216306 from MyBioSource
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shRNA set against Human ITGAX (NM_000887.3) - SHH321329 from Creative biogene
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shRNA set against Human ITGAX(NM_000887.3) - SHL183216 from Creative biogene
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Human ITGAX siRNA - orb262978 from Biorbyt
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ITGAX shRNA Plasmid (Human) - CHH2476 from Cohesion Biosciences
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ITGAX miRNA 3'UTR clone - MiUTR1H-05031 from Creative biogene
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