Gene Symbol | ITGAX |
---|---|
Entrez Gene | 3687 |
Alt Symbol | CD11C, SLEB6 |
Species | Human |
Gene Type | protein-coding |
Description | integrin, alpha X (complement component 3 receptor 4 subunit) |
Other Description | CD11 antigen-like family member C|integrin alpha-X|integrin, alpha X (antigen CD11C (p150), alpha polypeptide)|leu M5, alpha subunit|leukocyte adhesion glycoprotein p150,95 alpha chain|leukocyte adhesion receptor p150,95|leukocyte surface antigen p150,95, alpha subunit|myeloid membrane antigen, alpha subunit|p150 95 integrin alpha chain |
Swissprots | Q8IVA6 P20702 |
Accessions | AAA35661 AAA51620 EAW52140 EAW52141 EAW52142 P20702 AK074047 BAB84873 AK293367 BAG56881 AK296666 BAG59263 AK309642 AW014280 BC037577 BC038237 AAH38237 BM149283 CA308944 DA324567 DQ892486 ABM83412 DQ895697 ABM86623 M81695 AAA59180 XM_011545852 XP_011544154 XM_011545853 XP_011544155 XM_011545854 XP_011544156 XR_950797 NM_000887 NP_000878 NM_001286375 NP_001273304 |
Function | Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Predominantly expressed in monocytes and granulocytes. |
Top Pathways | Tuberculosis, Regulation of actin cytoskeleton |