| Gene Symbol |
TIMM13
|
| Entrez Gene |
26517
|
| Alt Symbol |
TIM13, TIM13B, TIMM13A, TIMM13B, ppv1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
translocase of inner mitochondrial membrane 13 homolog (yeast)
|
| Other Description |
mitochondrial import inner membrane translocase subunit Tim13|mitochondrial import inner membrane translocase subunit Tim13B
|
| Swissprots |
Q9Y5L4 P62206
|
| Accessions |
EAW69380 EAW69381 Q9Y5L4 AF144700 AAD39951 AF152352 AAF15102 AK024764 AL520160 BC008607 AAH08607 BI908100 BI966836 BQ015233 DA890574 DA947460 DQ891755 ABM82681 DQ894937 ABM85863 NM_012458 NP_036590
|
| Function |
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000269|PubMed:11489896}; Peripheral membrane protein {ECO:0000269|PubMed:11489896}; Intermembrane side {ECO:0000269|PubMed:11489896}.
|
| Tissue Specificity |
Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.
|