TIMM13
| Gene Symbol | TIMM13 |
|---|---|
| Entrez Gene | 26517 |
| Alt Symbol | TIM13, TIM13B, TIMM13A, TIMM13B, ppv1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | translocase of inner mitochondrial membrane 13 homolog (yeast) |
| Other Description | mitochondrial import inner membrane translocase subunit Tim13|mitochondrial import inner membrane translocase subunit Tim13B |
| Swissprots | Q9Y5L4 P62206 |
| Accessions | EAW69380 EAW69381 Q9Y5L4 AF144700 AAD39951 AF152352 AAF15102 AK024764 AL520160 BC008607 AAH08607 BI908100 BI966836 BQ015233 DA890574 DA947460 DQ891755 ABM82681 DQ894937 ABM85863 NM_012458 NP_036590 |
| Function | Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}. |
| Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:11489896}; Peripheral membrane protein {ECO:0000269|PubMed:11489896}; Intermembrane side {ECO:0000269|PubMed:11489896}. |
| Tissue Specificity | Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. |
Tim13A/B CRISPR/Cas9 KO Plasmid (h) - sc-408855 from Santa Cruz Biotechnology
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Tim13A/B HDR Plasmid (h) - sc-408855-HDR from Santa Cruz Biotechnology
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Tim13A/B Double Nickase Plasmid (h) - sc-408855-NIC from Santa Cruz Biotechnology
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Tim13A/B Double Nickase Plasmid (h2) - sc-408855-NIC-2 from Santa Cruz Biotechnology
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Tim13A/B CRISPR Activation Plasmid (h) - sc-408855-ACT from Santa Cruz Biotechnology
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Tim13A/B CRISPR Activation Plasmid (h2) - sc-408855-ACT-2 from Santa Cruz Biotechnology
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Tim13A/B Lentiviral Activation Particles (h) - sc-408855-LAC from Santa Cruz Biotechnology
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Tim13A/B Lentiviral Activation Particles (h2) - sc-408855-LAC-2 from Santa Cruz Biotechnology
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Tim13A/B siRNA (h) - sc-41257 from Santa Cruz Biotechnology
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Tim13A/B shRNA Plasmid (h) - sc-41257-SH from Santa Cruz Biotechnology
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Tim13A/B shRNA (h) Lentiviral Particles - sc-41257-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU022411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21357 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21357 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09091 from Sigma-Aldrich
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TIMM13 siRNA (Human) - CRH8843 from Cohesion Biosciences
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TIMM13 RNAi - H00026517-R01 from Novus Biologicals
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TIMM13 - MBS8204144 from MyBioSource
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shRNA set against Human TIMM13 (NM_012458.2) - SHH427384 from Creative biogene
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shRNA set against Human TIMM13(NM_012458.2) - SHL071148 from Creative biogene
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Human TIMM13 siRNA - orb269345 from Biorbyt
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TIMM13 shRNA Plasmid (Human) - CHH8843 from Cohesion Biosciences
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TIMM13 miRNA 3'UTR clone - MiUTR1H-10412 from Creative biogene
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