| Gene Symbol |
KCNJ8
|
| Entrez Gene |
3764
|
| Alt Symbol |
KIR6.1, uKATP-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, inwardly rectifying subfamily J, member 8
|
| Other Description |
ATP-sensitive inward rectifier potassium channel 8|inward rectifier K(+) channel Kir6.1|inwardly rectifying potassium channel KIR6.1|potassium channel, inwardly rectifying subfamily J member 8|potassium inwardly-rectifying channel, subfamily J, member 8
|
| Swissprots |
O00657 Q15842
|
| Accessions |
BAA08852 EAW96450 EAW96451 Q15842 AK291821 BAF84510 AL546327 BC000544 AAH00544 BQ003792 BQ009215 D50312 BAA08851 DQ891913 ABM82839 DQ895097 ABM86023 XM_005253358 XP_005253415 NM_004982 NP_004973
|
| Function |
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Predominantly detected in fetal and adult heart. {ECO:0000269|PubMed:9573340}.
|
| Top Pathways |
cGMP-PKG signaling pathway
|
![Western Blot: Kir6.1 Overexpression Lysate (Adult Normal) [NBL1-12174] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Kir6.1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/9169_Kir6.1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-12174-img0002.jpg)