KCNJ8

Gene Symbol KCNJ8
Entrez Gene 3764
Alt Symbol KIR6.1, uKATP-1
Species Human
Gene Type protein-coding
Description potassium channel, inwardly rectifying subfamily J, member 8
Other Description ATP-sensitive inward rectifier potassium channel 8|inward rectifier K(+) channel Kir6.1|inwardly rectifying potassium channel KIR6.1|potassium channel, inwardly rectifying subfamily J member 8|potassium inwardly-rectifying channel, subfamily J, member 8
Swissprots O00657 Q15842
Accessions BAA08852 EAW96450 EAW96451 Q15842 AK291821 BAF84510 AL546327 BC000544 AAH00544 BQ003792 BQ009215 D50312 BAA08851 DQ891913 ABM82839 DQ895097 ABM86023 XM_005253358 XP_005253415 NM_004982 NP_004973
Function This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Predominantly detected in fetal and adult heart. {ECO:0000269|PubMed:9573340}.
Top Pathways cGMP-PKG signaling pathway

KIR6.1 (R-14) - sc-11224 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KIR6.1 (R-14): sc-11224. Western blot analysis of KIR6.1 expression in mouse heart (A) and rat skeletal muscle (B) extracts.

KIR6.1 (C-16) - sc-11225 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KIR6.1 (C-16): sc-11225. Immunofluorescence staining of methanol-fixed Sol8 cells showing membrane localization.

KIR6.1 (H-80) - sc-20808 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
KIR6.1 (H-80): sc-20808. Immunoperoxidase staining of formalin fixed, paraffin-embedded human stomach tissue showing nuclear staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Anti-Kir6.1 antibody - ab80972 from Abcam

Prices $370.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal
Anti-Kir6.1 antibody (ab80972) at 1 µg/ml + Brain (Human) Membrane Lysate - adult normal tissue (ab29456) at 20 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Kir6.1 antibody - ab105100 from Abcam

Host Goat
Clonality Polyclonal

Anti-Kir6.1 antibody - N-terminal - ab170676 from Abcam

Host Rabbit
Clonality Polyclonal
Immunohistochemistical analysis of formalin fixed and paraffin embedded Human heart tissue labeling Kir6.1 with ab170676 at 1/10 dilution followed by peroxidase conjugation of the secondary antibody and DAB staining.

Anti-KCNJ8 / Kir6.1 Antibody (aa4-33) - LS-C165436 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
KCNJ8 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human heart tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-KCNJ8 / Kir6.1 Antibody (C-Terminus) IHC-plus™ - LS-B5616 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNJ8 / Kir6.1 antibody IHC of human colon, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5616 concentration 5 ug/ml.

Anti-KCNJ8 / Kir6.1 Antibody (Cytoplasmic Domain) - LS-C94175 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNJ8 / Kir6.1 Antibody (aa4-33, FITC) - LS-C260950 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ8 / Kir6.1 Antibody (aa4-33, APC) - LS-C260946 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ8 / Kir6.1 Antibody (aa4-33, AP) - LS-C260947 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ8 / Kir6.1 Antibody (aa4-33, Biotin) - LS-C260948 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ8 / Kir6.1 Antibody (aa4-33, PE) - LS-C260954 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ8 / Kir6.1 Antibody (aa4-33, Azide-free, HRP) - LS-C260952 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNJ8 / Kir6.1 Antibody (aa3-33) - LS-C322397 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Kir6.1 Antibody - NBP1-87710 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Kir6.1 Antibody [NBP1-87710] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-295

Kir6.1 Antibody - NBP1-70370 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

Kir6.1 Antibody - NBP1-20159 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

kir 6.1 Polyclonal Antibody - bs-6468R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded mouse heart tissue labeled with Anti-kir 6.1/IRK8 Polyclonal Antibody, Unconjugated (bs-6468R) at 1:200 followed by conjugation to the secondary antibody

Anti-Potassium Channel KIR6.1 antibody produced in rabbit - P0874 from Sigma-Aldrich

Prices $214.00, $572.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-K<SUB>ir</SUB>6.1: <B>Cat. No. P0874</B>: Immunohistochemical stain of pregnant Rat longitudinal section of the myometrium using Anti-K<SUB>ir</SUB>6.1 antibody, (1:50). Strong and specific staining is evident in smooth muscles cells both in the myometrium (blue arrow) and muscular layers of blood vessels (green arrow). Peroxidase reaction with DAB were used for the color reaction. Hematoxilin is used as the counterstain.

Anti-KCNJ8 antibody produced in rabbit - HPA031066 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KCNJ8: <B>Cat. No. HPA031066</B>: Immunohistochemical staining of human skin shows strong cytoplasmic positivity.

Anti-KCNJ8 antibody produced in rabbit - SAB2101220 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KCNJ8: <B>Cat. No.SAB2101220</B>: KCNJ8 in HeLa cell lysate with KCNJ8 antibody at 1.0 μg/mL.

KCNJ8 antibody - middle region (ARP35169_P050) - ARP35169_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KCNJ8-Antibody-N-term - AP12302a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
KCNJ8 Antibody (N-term) (Cat. #AP12302a) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the KCNJ8 antibody detected the KCNJ8 protein (arrow).
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