IDH2

Gene Symbol IDH2
Entrez Gene 3418
Alt Symbol D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH
Species Human
Gene Type protein-coding
Description isocitrate dehydrogenase 2 (NADP+), mitochondrial
Other Description NADP(+)-specific ICDH|isocitrate dehydrogenase [NADP], mitochondrial|oxalosuccinate decarboxylase
Swissprots B4DFL2 B2R6L6 P48735 Q96GT3
Accessions CBN62262 CBN63691 EAX02082 EAX02083 P48735 AK222916 BAD96636 AK294148 BAG57473 AK299987 BAG61808 AK312627 BAG35513 AK316388 BAH14759 BC009244 AAH09244 BC071828 AAH71828 DQ892817 ABM83743 DQ896063 ABM87062 HY010337 X69433 CAA49208 NM_001289910 NP_001276839 NM_001290114 NP_001277043 NM_002168 NP_002159
Function Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
Subcellular Location Mitochondrion.
Top Pathways Citrate cycle (TCA cycle), Peroxisome, Glutathione metabolism, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism

IDH2 (D7H6Q) Rabbit mAb - 12652 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7H6Q
Western blot analysis of extracts from various cell lines using IDH2 (D7H6Q) Rabbit mAb.

IDH1/2 (W-16) - sc-55668 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IDH1/2 (W-16): sc-55668. Western blot analysis of IDH2 expression in DU 145 whole cell lysate.

IDH2 (B-6) - sc-374476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IDH2 (B-6): sc-374476. Western blot analysis of IDH2 expression in Caki-1 whole cell lysate.

IDH2 (L-15) - sc-55664 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IDH2 (H-40) - sc-134923 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IDH2 (H-40): sc-134923. Western blot analysis of IDH2 expression in HEK293 (A) and Caki-1 (B) whole cell lysates.

IDH2 (N-16) - sc-55666 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IDH2 antibody - ab55271 from Abcam

Prices $391.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
IDH2 antibody (ab55271) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.

Anti-IDH2 antibody - ab177512 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IDH2 antibody (ab177512) at 0.4 µg/mlLane 1 : Whole cell lysate from 293T cellsLane 2 : Whole cell lysate from HeLa cellsLane 3 : Whole cell lysate from Jurkat cellsLane 4 : Whole cell lysate from TCMK-1 cellsLane 5 : Whole cell lysate from NIH3T3 cellsLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-IDH2 antibody [EPR7576] - ab129180 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7576
Overlay histogram showing MCF7 cells stained with ab129180 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab129180, 1/10000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in MCF7 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-IDH2 antibody [EPR7577] - ab131263 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7577
Overlay histogram showing MCF7 cells stained with ab131263 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab131263, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in MCF7 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-IDH2 antibody [GT673] - ab184196 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT673
Anti-IDH2 antibody [GT673] (ab184196) at 1/1000 dilution + rat brain lysate at 50 µg

Anti-IDH2 Antibody (aa144-193) - LS-C102300 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IDH2 antibody LS-C102300 Western blot of Fetal Muscle lysate.

Anti-IDH2 Antibody (C-Terminus, clone EPR7577) - LS-C154548 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7577
IHC of paraffin-embedded human liver tissue using anti-IDH2 antibody.

Anti-IDH2 Antibody (N-Terminus) - LS-C115860 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of IDH2 in mouse heart tissue with IDH2 antibody at 20 ug/ml.

Anti-IDH2 Antibody (aa194-243) - LS-C199893 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Caki-1 cells, using IDH2 antibody.

Anti-IDH2 Antibody (Internal, clone EPR7576) IHC-plus™ - LS-B9298 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7576
Anti-IDH / IDH2 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-IDH2 Antibody - LS-C310687 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IDH / IDH2 Antibody (aa354-452, Azide-free) - LS-C327670 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-IDH2 Antibody (aa56-345) - LS-C185556 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded normal gastric epithelium (gland) using IDH2 antibody at 1:100 dilution.

Anti-IDH2 Antibody (aa402-452) - LS-C290743 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human IDH2 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-IDH2 antibody used for IP at 6 ug/mg lysate. For blotting immunoprecipitated IDH2, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-IDH2 Antibody (aa418-429) IHC-plus™ - LS-B8349 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-IDH / IDH2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8349 dilution 3.75 ug/ml.

Anti-IDH2 Antibody (clone 5F11) IHC-plus™ - LS-B4358 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5F11
Anti-IDH2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4358 concentration 5 ug/ml.

Anti-IDH2 Antibody - LS-C346272 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of U20S cell using IDH2 antibody. Blue: DAPI for nuclear staining.

IDH2 Antibody - NBP2-22166 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: IDH2 Antibody [NBP2-22166] - Western blot analysis of Caki-1 cell lysate (A), human skeletal muscle tissue (B), mouse skeletal muscle tissue (C), and rat skeletal muscle tissue (D) using IDH2 antibody at a concentration of 2 ug/ml.

IDH2 Antibody - NBP1-85784 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: IDH2 Antibody [NBP1-85784] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.
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