TRIM22

Gene Symbol	TRIM22
Entrez Gene	10346
Alt Symbol	GPSTAF50, RNF94, STAF50
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 22
Other Description	50 kDa-stimulated trans-acting factor|E3 ubiquitin-protein ligase TRIM22|RING finger protein 94|staf-50|stimulated trans-acting factor (50 kDa)|tripartite binding motif 22|tripartite motif protein TRIM22|tripartite motif-containing 22|tripartite motif-containing protein 22
Swissprots	Q8IYM9 Q05CQ0 Q15521
Accessions	EAW68767 EAW68768 EAW68769 EAW68770 Q8IYM9 AK290434 BAF83123 AK298715 BAG60871 AK298934 BAG61037 AK301192 BAG62772 AK308221 AK308796 AK310098 AK311659 AL360134 AL360187 AL360190 AM040752 CAJ13842 BC022281 AAH22281 BC035582 AAH35582 CD621768 DC364428 DQ891201 ABM82127 DQ894384 ABM85310 HQ842635 ADY69767 X82200 CAA57684 NM_001199573 NP_001186502 NM_006074 NP_006065
Function	Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:18656448, ECO:0000269|PubMed:19218198, ECO:0000269|PubMed:19585648}.
Subcellular Location	Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominanltly into the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
Tissue Specificity	Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues. {ECO:0000269|PubMed:7797467}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Staf-50 (C-20) - sc-68829 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Staf-50 (E-15) - sc-68830 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Staf-50 (H-40) - sc-367982 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-Trim22 antibody - ab81642 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Trim22 antibody - ab86116 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Trim22 antibody - ab68071 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Trim22 antibody [1D3] - ab140966 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1D3

Anti-Trim22 antibody - N-terminal - ab174362 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (aa74-123) IHC-plus™ - LS-B5884 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (aa61-406, clone 1D3) - LS-C337842 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1D3

Anti-STAF50 / TRIM22 Antibody (aa61-406, clone 1D11) - LS-C337848 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1D11

Anti-STAF50 / TRIM22 Antibody (Internal) - LS-C145090 from LifeSpan Bioscience Prices $285.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (Internal) - LS-C153440 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (aa67-97, AP) - LS-C272174 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (aa67-97, APC) - LS-C272175 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (aa67-97, Biotin) - LS-C272176 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (aa67-97, Azide-free, HRP) - LS-C272177 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (aa67-97, FITC) - LS-C272178 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (aa359-408) - LS-C101706 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (aa67-97, PE) - LS-C272179 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (aa67-97) - LS-C325932 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-STAF50 / TRIM22 Antibody (clone 2G2) - LS-C174260 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2G2

Anti-STAF50 / TRIM22 Antibody (clone 1A10) - LS-C174167 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1A10

Anti-STAF50 / TRIM22 Antibody (aa67-97) - LS-C156975 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Trim22 Antibody - NBP1-81795 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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