| Gene Symbol |
TRIM22
|
| Entrez Gene |
10346
|
| Alt Symbol |
GPSTAF50, RNF94, STAF50
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 22
|
| Other Description |
50 kDa-stimulated trans-acting factor|E3 ubiquitin-protein ligase TRIM22|RING finger protein 94|staf-50|stimulated trans-acting factor (50 kDa)|tripartite binding motif 22|tripartite motif protein TRIM22|tripartite motif-containing 22|tripartite motif-containing protein 22
|
| Swissprots |
Q8IYM9 Q05CQ0 Q15521
|
| Accessions |
EAW68767 EAW68768 EAW68769 EAW68770 Q8IYM9 AK290434 BAF83123 AK298715 BAG60871 AK298934 BAG61037 AK301192 BAG62772 AK308221 AK308796 AK310098 AK311659 AL360134 AL360187 AL360190 AM040752 CAJ13842 BC022281 AAH22281 BC035582 AAH35582 CD621768 DC364428 DQ891201 ABM82127 DQ894384 ABM85310 HQ842635 ADY69767 X82200 CAA57684 NM_001199573 NP_001186502 NM_006074 NP_006065
|
| Function |
Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:18656448, ECO:0000269|PubMed:19218198, ECO:0000269|PubMed:19585648}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominanltly into the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
|
| Tissue Specificity |
Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues. {ECO:0000269|PubMed:7797467}.
|