TRIM22

Gene Symbol TRIM22
Entrez Gene 10346
Alt Symbol GPSTAF50, RNF94, STAF50
Species Human
Gene Type protein-coding
Description tripartite motif containing 22
Other Description 50 kDa-stimulated trans-acting factor|E3 ubiquitin-protein ligase TRIM22|RING finger protein 94|staf-50|stimulated trans-acting factor (50 kDa)|tripartite binding motif 22|tripartite motif protein TRIM22|tripartite motif-containing 22|tripartite motif-containing protein 22
Swissprots Q8IYM9 Q05CQ0 Q15521
Accessions EAW68767 EAW68768 EAW68769 EAW68770 Q8IYM9 AK290434 BAF83123 AK298715 BAG60871 AK298934 BAG61037 AK301192 BAG62772 AK308221 AK308796 AK310098 AK311659 AL360134 AL360187 AL360190 AM040752 CAJ13842 BC022281 AAH22281 BC035582 AAH35582 CD621768 DC364428 DQ891201 ABM82127 DQ894384 ABM85310 HQ842635 ADY69767 X82200 CAA57684 NM_001199573 NP_001186502 NM_006074 NP_006065
Function Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:18389079, ECO:0000269|PubMed:18656448, ECO:0000269|PubMed:19218198, ECO:0000269|PubMed:19585648}.
Subcellular Location Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominanltly into the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
Tissue Specificity Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues. {ECO:0000269|PubMed:7797467}.

Human Trim22 full length protein - ab153072 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153072 on a 12.5% SDS-PAGE stained with Coomassie Blue.

STAF50 / TRIM22 Antibody Blocking Peptide - LS-E10895 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

STAF50 / TRIM22 Antibody Blocking Peptide - LS-E6694 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

STAF50 / TRIM22 Antibody Blocking Peptide - LS-E13945 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human Trim22 Protein - H00010346-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

TRIM22-AntibodyN-term-Blocking-peptide - BP19529a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

TRIM22 Blocking Peptide - 33R-9485 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

TRIM22 / RNF94 - H00010346-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

TRIM22 / RNF94 - H00010346-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

TRIM22 fusion protein - ag6938 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

TRIM22 fusion protein - ag4683 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human E3 ubiquitin-protein ligase TRIM22(TRIM22) - CSB-YP810305HU CSB-EP810305HU CSB-BP810305HU CSB-MP810305HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

TRIM22 Protein - abx163027 from Abbexa

Category Protein
Species Human

Trim22 Recombinant Protein Antigen - NBP1-81795PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

TRIM22 Peptide, Human - M34GP16574H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

E3 ubiquitin-protein ligase TRIM22 (TRIM22), Recombinant Protein - MBS1401200 from MyBioSource

Category Protein
Prices $1,285.00, $1,285.00, $1,505.00, $1,505.00, $2,110.00, $2,110.00, $2,570.00, $2,570.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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