| Gene Symbol |
AREL1
|
| Entrez Gene |
9870
|
| Alt Symbol |
KIAA0317
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apoptosis resistant E3 ubiquitin protein ligase 1
|
| Other Description |
apoptosis-resistant E3 ubiquitin protein ligase 1
|
| Swissprots |
Q7LDY1 O15033 B4E2C7 Q8IYY9
|
| Accessions |
AAF61276 EAW81186 O15033 AB002315 BAA20775 AK296912 BAG59467 AK304217 BAG65089 BC032944 AAH32944 BI459956 BX248747 CAD66554 XM_005268244 XP_005268301 XM_006720344 XP_006720407 XM_011537415 XP_011535717 XM_011537416 XP_011535718 XM_011537417 XP_011535719 XM_011537418 XP_011535720 NM_014821 NM_001039479 NP_001034568
|
| Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. {ECO:0000269|PubMed:23479728}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:23479728}.
|
![Western Blot: KIAA0317 Overexpression Lysate (Adult Normal) [NBP2-08573] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KIAA0317.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3330_KIAA0317%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08573-img0001.jpg)