| Gene Symbol |
ADAM2
|
| Entrez Gene |
2515
|
| Alt Symbol |
CRYN1, CRYN2, CT15, FTNB, PH-30b, PH30, PH30-beta
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ADAM metallopeptidase domain 2
|
| Other Description |
cancer/testis antigen 15|disintegrin and metalloproteinase domain-containing protein 2|fertilin subunit beta
|
| Swissprots |
Q9UQQ8 P78326 Q99965
|
| Accessions |
CBH30599 EAW63273 EAW63274 EAW63275 Q99965 AJ133005 CAB40813 AK301734 BAG63199 BC034957 AAH34957 BC064547 AAH64547 BG719616 BI460477 DQ891615 ABM82541 DQ894807 ABM85733 U38805 AAD04206 U52370 AAC51110 X99374 CAA67753 XM_005273468 XP_005273525 XM_006725119 XP_006725182 XM_011544479 XP_011542781 XM_011544480 XP_011542782 XM_011546571 XP_011544873 XM_011546572 XP_011544874 NM_001278113 NP_001265042 NM_001278114 NP_001265043 NM_001464 NP_001455
|
| Function |
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
|