DMRT1

Gene Symbol DMRT1
Entrez Gene 1761
Alt Symbol CT154, DMT1
Species Human
Gene Type protein-coding
Description doublesex and mab-3 related transcription factor 1
Other Description DM domain expressed in testis 1|DM domain expressed in testis protein 1|doublesex- and mab-3-related transcription factor 1
Swissprots Q9Y5R6 Q6T1H8 B2R913 Q8IW77 Q6T1H9
Accessions EAW58820 Q9Y5R6 AF130728 AAD40474 AJ276801 CAB82851 AK310336 AK313594 BAG36360 AL162131 CAB82427 AY442914 AAR89619 AY442915 AAR89620 BC040847 AAH40847 BG202785 EU446468 ABZ91997 XM_006716732 XP_006716795 XM_011517770 XP_011516072 XM_011517771 XP_011516073 XM_011517772 XP_011516074 XM_011517773 XP_011516075 NM_021951 NP_068770
Function Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00070}.
Tissue Specificity Testis-specific. Expressed in prostate cancer (at protein level). {ECO:0000269|PubMed:10857744, ECO:0000269|PubMed:23436708}.

DMRT1 (A-9) - sc-377167 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DMRT1 (A-9): sc-sc-377167. Western blot analysis of DMRT1 expression in F9 whole cell lysate.

DMRT1 (S-12) - sc-104885 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DMRT1 (S-12): sc-104885. Western blot analysis of DMRT1 expression in human testis tissue extract.

DMRT1 (H-240) - sc-98341 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DMRT1 (H-240): sc-98341. Western blot analysis of DMRT1 expression in HS 181.Tes whole cell lysate.

DMRT1 (SS6) - sc-101024 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
DMRT1 (SS6): sc-101024. Western blot analysis of DMRT1 expression in HL-60 whole cell lysate.

Anti-DMRT1 antibody - ab81786 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DMRT1 antibody (ab81786) at 1 µg/ml + fetal brain lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-DMRT1 antibody - ab54732 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DMRT1 antibody - ab171874 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-DMRT1 antibody (ab171874) at 1 µg/mlLane 1 : DMRT1 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgGb at 1/2500 dilution

Anti-DMRT1 antibody [EPR6936] - ab126741 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6936
All lanes : Anti-DMRT1 antibody [EPR6936] (ab126741) at 1/1000 dilutionLane 1 : Human testis lysateLane 2 : HL-60 lysateLane 3 : Human seminoma lysateLysates/proteins at 10 µg per lane.SecondaryGoat-anti-rabbit HRP at 1/2000 dilutiondeveloped using the ECL technique

Anti-DMRT1 antibody [EPR6936-209] - ab166893 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6936-209
Immunohistochemical analysis of paraffin embedded Human testis tissue labeling DMRT1 with ab166893 at 1/50 dilution.

Anti-DMRT1 antibody - C-terminal - ab138948 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DMRT1 antibody - C-terminal (ab138948) at 1/100 dilution + MCF-7 cell lysate at 35 µg

Anti-DMRT1 Antibody (aa1-210, clone 1G10) - LS-C340305 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G10
Western blot of extracts (10ug) from 2 different cell lines by using anti-DMRT1 monoclonal antibody at 1:200 dilution.

Anti-DMT1 / DMRT1 Antibody (aa1-374, clone 10B2752, Azide-free) - LS-C183572 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10B2752

Anti-DMRT1 Antibody (aa296-322, AP) - LS-C234629 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DMRT1 Antibody (aa296-322, APC) - LS-C234630 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DMRT1 Antibody (aa296-322, Biotin) - LS-C234631 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DMRT1 Antibody (aa296-322, FITC) - LS-C234632 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DMRT1 Antibody (aa296-322, PE) - LS-C234633 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DMRT1 Antibody (C-Terminus) - LS-C116066 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DMRT1 antibody LS-C116066 Western blot of NIH3T3 cell lysate.

Anti-DMRT1 Antibody (N-Terminus, clone EPR6936) - LS-C152376 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6936
Western blot analysis on (A) human testis, (B) HL-60, and (C) human seminoma lysates using anti-DMRT1 antibody.

Anti-DMRT1 Antibody (aa296-322, Azide-free, HRP) - LS-C249840 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DMRT1 Antibody - LS-C307264 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-DMRT1 Antibody (N-Terminus) - LS-C82043 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-DMRT1 Antibody (aa296-322) - LS-C159467 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DMRT1 Antibody western blot of MCF-7 cell line lysates (35 ug/lane). The DMRT1 antibody detected the DMRT1 protein (arrow).

Anti-DMRT1 Antibody - LS-C310151 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DMRT1 Antibody (aa92-141) - LS-C205636 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DMT1 / DMRT1 antibody Western Blot of Esophagus Tumor. Antibody dilution: 1 ug/ml.
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