| Gene Symbol | DMRT1 |
|---|---|
| Entrez Gene | 1761 |
| Alt Symbol | CT154, DMT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | doublesex and mab-3 related transcription factor 1 |
| Other Description | DM domain expressed in testis 1|DM domain expressed in testis protein 1|doublesex- and mab-3-related transcription factor 1 |
| Swissprots | Q9Y5R6 Q6T1H8 B2R913 Q8IW77 Q6T1H9 |
| Accessions | EAW58820 Q9Y5R6 AF130728 AAD40474 AJ276801 CAB82851 AK310336 AK313594 BAG36360 AL162131 CAB82427 AY442914 AAR89619 AY442915 AAR89620 BC040847 AAH40847 BG202785 EU446468 ABZ91997 XM_006716732 XP_006716795 XM_011517770 XP_011516072 XM_011517771 XP_011516073 XM_011517772 XP_011516074 XM_011517773 XP_011516075 NM_021951 NP_068770 |
| Function | Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00070}. |
| Tissue Specificity | Testis-specific. Expressed in prostate cancer (at protein level). {ECO:0000269|PubMed:10857744, ECO:0000269|PubMed:23436708}. |
DMRT1 CRISPR/Cas9 KO Plasmid (h) - sc-402856 from Santa Cruz Biotechnology
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DMRT1 HDR Plasmid (h) - sc-402856-HDR from Santa Cruz Biotechnology
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DMRT1 Double Nickase Plasmid (h) - sc-402856-NIC from Santa Cruz Biotechnology
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DMRT1 Double Nickase Plasmid (h2) - sc-402856-NIC-2 from Santa Cruz Biotechnology
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DMRT1 CRISPR Activation Plasmid (h) - sc-402856-ACT from Santa Cruz Biotechnology
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DMRT1 CRISPR Activation Plasmid (h2) - sc-402856-ACT-2 from Santa Cruz Biotechnology
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DMRT1 Lentiviral Activation Particles (h) - sc-402856-LAC from Santa Cruz Biotechnology
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DMRT1 Lentiviral Activation Particles (h2) - sc-402856-LAC-2 from Santa Cruz Biotechnology
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DMRT1 siRNA (h) - sc-92489 from Santa Cruz Biotechnology
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DMRT1 shRNA Plasmid (h) - sc-92489-SH from Santa Cruz Biotechnology
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DMRT1 shRNA (h) Lentiviral Particles - sc-92489-V from Santa Cruz Biotechnology
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DMRT1 RNAi - H00001761-R01 from Novus Biologicals
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MISSION® esiRNA - EHU001081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7313 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7313 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07448 from Sigma-Aldrich
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DMRT1 siRNA (Human) - CRH1224 from Cohesion Biosciences
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DMRT1 - MBS8215752 from MyBioSource
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shRNA set against Human DMRT1(NM_021951.2) - SHH008489 from Creative biogene
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Human DMRT1 siRNA - orb261726 from Biorbyt
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DMRT1 shRNA Plasmid (Human) - CHH1224 from Cohesion Biosciences
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DMRT1 miRNA 3'UTR clone - MiUTR1H-02889 from Creative biogene
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