| Gene Symbol |
DMRT1
|
| Entrez Gene |
1761
|
| Alt Symbol |
CT154, DMT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
doublesex and mab-3 related transcription factor 1
|
| Other Description |
DM domain expressed in testis 1|DM domain expressed in testis protein 1|doublesex- and mab-3-related transcription factor 1
|
| Swissprots |
Q9Y5R6 Q6T1H8 B2R913 Q8IW77 Q6T1H9
|
| Accessions |
EAW58820 Q9Y5R6 AF130728 AAD40474 AJ276801 CAB82851 AK310336 AK313594 BAG36360 AL162131 CAB82427 AY442914 AAR89619 AY442915 AAR89620 BC040847 AAH40847 BG202785 EU446468 ABZ91997 XM_006716732 XP_006716795 XM_011517770 XP_011516072 XM_011517771 XP_011516073 XM_011517772 XP_011516074 XM_011517773 XP_011516075 NM_021951 NP_068770
|
| Function |
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00070}.
|
| Tissue Specificity |
Testis-specific. Expressed in prostate cancer (at protein level). {ECO:0000269|PubMed:10857744, ECO:0000269|PubMed:23436708}.
|