DMRT1

Gene Symbol DMRT1
Entrez Gene 1761
Alt Symbol CT154, DMT1
Species Human
Gene Type protein-coding
Description doublesex and mab-3 related transcription factor 1
Other Description DM domain expressed in testis 1|DM domain expressed in testis protein 1|doublesex- and mab-3-related transcription factor 1
Swissprots Q9Y5R6 Q6T1H8 B2R913 Q8IW77 Q6T1H9
Accessions EAW58820 Q9Y5R6 AF130728 AAD40474 AJ276801 CAB82851 AK310336 AK313594 BAG36360 AL162131 CAB82427 AY442914 AAR89619 AY442915 AAR89620 BC040847 AAH40847 BG202785 EU446468 ABZ91997 XM_006716732 XP_006716795 XM_011517770 XP_011516072 XM_011517771 XP_011516073 XM_011517772 XP_011516074 XM_011517773 XP_011516075 NM_021951 NP_068770
Function Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00070}.
Tissue Specificity Testis-specific. Expressed in prostate cancer (at protein level). {ECO:0000269|PubMed:10857744, ECO:0000269|PubMed:23436708}.

Human DMRT1 full length protein - ab114958 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE showing ab114958 at approximately 67.14kDa. Stained with Coomassie Blue.

Recombinant Human DMRT1 Protein - H00001761-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

DMRT1-Antibody-C-term-Blocking-Peptide - BP19143b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

DMRT1 - H00001761-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

DMRT1 - H00001761-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

DMRT1 fusion protein - ag5547 from Proteintech Group

Category Protein
Source E. coli-derived, T-HIS
Species Human

Recombinant Human DMRT1 - DMRT1-27093TH from Creative Biomart

Category Protein
Source Wheat germ

Recombinant Human Doublesex- and mab-3-related transcription factor 1(DMRT1) - CSB-YP896914HU CSB-EP896914HU CSB-BP896914HU CSB-MP896914HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

DMRT1 Protein - abx163228 from Abbexa

Category Protein
Species Human

DMRT1 - TP308108 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
DMRT1

DMRT1 Recombinant Protein Antigen - NBP1-84071PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

DMRT1 Peptide, Human - M34GP04368H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Doublesex-and mab-3-related transcription factor 1 (DMRT1), Recombinant Protein - MBS1335443 from MyBioSource

Category Protein
Prices $1,140.00, $1,140.00, $1,370.00, $1,370.00, $1,815.00, $1,815.00, $2,280.00, $2,280.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

DMRT1 fusion protein - Ag28015 from Proteintech Group

Category Protein
Source E. coli -derived, PET28a
Species Human
Search more