| Gene Symbol | Rnls |
|---|---|
| Entrez Gene | 67795 |
| Alt Symbol | 6530404N21Rik, AI452315, AW060440, C10orf59 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | renalase, FAD-dependent amine oxidase |
| Other Description | MAO-C|alpha-NAD(P)H oxidase/anomerase|mMAO-C|monoamine oxidase-C|renalase|rnls |
| Swissprots | A7RDN6 Q80W75 Q3TD88 |
| Accessions | A7RDN6 AK014866 AK018322 AK170321 BAE41716 BC052355 AAH52355 DQ788834 ABG82016 NM_001146342 NP_001139814 NM_001167818 NP_001161290 |
| Function | Catalyzes the oxidation of the less abundant alpha- NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:17846919}. |
| Tissue Specificity | Expressed predominantly in kidney and testis with lower levels in liver, heart and embryo and weak expression in brain and skeletal muscle. {ECO:0000269|PubMed:17846919}. |
Renalase, Rnls, Mouse, ELISA Kit - E1103m from ARP American Research Products
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Mouse Renalase ELISA Kit - abx254872 from Abbexa
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Mouse Renalase ELISA Kit - EKE52266 from Biomatik
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Rnls - EKM1040 from Nordic BioSite
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RNLS ELISA Kit (Mouse) (OKEH00772) - OKEH00772 from Aviva Systems Biology
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Mouse Rnls ELISA Kit - E066217 from Biobool
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Mouse Renalase ELISA Kit - EK2751 from Signalway Antibody
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Renalase, ELISA Kit - MBS2885959 from MyBioSource
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Renalase, ELISA Kit - MBS9426588 from MyBioSource
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