Gene Symbol | Rnls |
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Entrez Gene | 67795 |
Alt Symbol | 6530404N21Rik, AI452315, AW060440, C10orf59 |
Species | Mouse |
Gene Type | protein-coding |
Description | renalase, FAD-dependent amine oxidase |
Other Description | MAO-C|alpha-NAD(P)H oxidase/anomerase|mMAO-C|monoamine oxidase-C|renalase|rnls |
Swissprots | A7RDN6 Q80W75 Q3TD88 |
Accessions | A7RDN6 AK014866 AK018322 AK170321 BAE41716 BC052355 AAH52355 DQ788834 ABG82016 NM_001146342 NP_001139814 NM_001167818 NP_001161290 |
Function | Catalyzes the oxidation of the less abundant alpha- NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:17846919}. |
Tissue Specificity | Expressed predominantly in kidney and testis with lower levels in liver, heart and embryo and weak expression in brain and skeletal muscle. {ECO:0000269|PubMed:17846919}. |
Renalase Antibody - NBP1-98475 from Novus Biologicals
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Anti-RNLS antibody produced in rabbit - SAB2107417 from Sigma-Aldrich
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Rnls antibody - middle region (ARP59612_P050) - ARP59612_P050 from Aviva Systems Biology
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Renalase Antibody - abx100287 from Abbexa
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Anti-Renalase (RNLS) - 20-4687 from ARP American Research Products
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Rnls Antibody - GWB-MV665H from Genway Biotech
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Anti-RNLS (aa 203-252) polyclonal antibody - DPABH-28423 from Creative Diagnostics
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Polyclonal Antibody to Renalase (RNLS) - PAC845Mu01 from Cloud-clone
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Polyclonal Antibody to Renalase (RNLS) - PAC845Mu02 from Cloud-clone
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Biotin-Linked Antibody to Renalase (RNLS) - PAC845Mu71 from Cloud-clone
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Renalase (aa 134 to 147) antibody, Internal - GTX88868 from GeneTex
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Rnls-antibody-middle-region-AI14427 - AI14427 from Abgent, a WuXi AppTec company
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Renalase (RNLS) Polyclonal Antibody - CAU23815 from Biomatik
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Anti-Renalase (aa 134 to 147) Goat Antibody - EB07855 from ARP American Research Products
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Rnls antibody - middle region : Biotin (ARP59612_P050-Biotin) - ARP59612_P050-Biotin from Aviva Systems Biology
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Rnls antibody - middle region : FITC (ARP59612_P050-FITC) - ARP59612_P050-FITC from Aviva Systems Biology
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Rnls antibody - middle region : HRP (ARP59612_P050-HRP) - ARP59612_P050-HRP from Aviva Systems Biology
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Renalase (RNLS), Polyclonal Antibody - MBS2068535 from MyBioSource
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Renalase (RNLS), Polyclonal Antibody - MBS2068536 from MyBioSource
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Renalase (RNLS), Polyclonal Antibody - MBS2068537 from MyBioSource
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Renalase (RNLS), Polyclonal Antibody - MBS2068538 from MyBioSource
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Renalase (RNLS), Polyclonal Antibody - MBS2068539 from MyBioSource
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Renalase (RNLS), Polyclonal Antibody - MBS2068540 from MyBioSource
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