| Gene Symbol |
Rnls
|
| Entrez Gene |
67795
|
| Alt Symbol |
6530404N21Rik, AI452315, AW060440, C10orf59
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
renalase, FAD-dependent amine oxidase
|
| Other Description |
MAO-C|alpha-NAD(P)H oxidase/anomerase|mMAO-C|monoamine oxidase-C|renalase|rnls
|
| Swissprots |
A7RDN6 Q80W75 Q3TD88
|
| Accessions |
A7RDN6 AK014866 AK018322 AK170321 BAE41716 BC052355 AAH52355 DQ788834 ABG82016 NM_001146342 NP_001139814 NM_001167818 NP_001161290
|
| Function |
Catalyzes the oxidation of the less abundant alpha- NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:17846919}.
|
| Tissue Specificity |
Expressed predominantly in kidney and testis with lower levels in liver, heart and embryo and weak expression in brain and skeletal muscle. {ECO:0000269|PubMed:17846919}.
|
![Western Blot: Renalase Overexpression Lysate (Adult Normal) [NBP2-10608] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Renalase.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/906_Renalase%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10608-img0001.jpg)