| Gene Symbol |
DYNLRB1
|
| Entrez Gene |
83658
|
| Alt Symbol |
BITH, BLP, DNCL2A, DNLC2A, ROBLD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dynein, light chain, roadblock-type 1
|
| Other Description |
ROBL/LC7-like 1|bithoraxoid-like protein|dynein light chain roadblock-type 1|dynein, cytoplasmic, light polypeptide 2A|dynein-associated protein Km23|roadblock domain-containing protein 1
|
| Swissprots |
Q5TC72 B1AKR5 Q96IV3 Q9NQM2 Q9NP97
|
| Accessions |
EAW76267 Q9NP97 AF132750 AAL75951 AF161511 AAF29126 AF165516 AAF86646 AF178431 AAK95342 AK026864 AK097281 AK294214 BAG57523 AY026513 AAK18712 BC002481 AAH02481 BC007223 BG110161 BG419592 BM561321 BM791453 BQ639804 BU163605 CB149456 XM_005260568 XP_005260625 NM_001281727 NP_001268656 NM_001281728 NP_001268657 NM_001281729 NP_001268658 NM_014183 NP_054902 NM_177953 NP_808852 NR_104032
|
| Function |
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
|
| Subcellular Location |
Cytoplasm, cytoskeleton.
|
| Tissue Specificity |
High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients. {ECO:0000269|PubMed:11750132}.
|