Gene Symbol | DYNLRB1 |
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Entrez Gene | 83658 |
Alt Symbol | BITH, BLP, DNCL2A, DNLC2A, ROBLD1 |
Species | Human |
Gene Type | protein-coding |
Description | dynein, light chain, roadblock-type 1 |
Other Description | ROBL/LC7-like 1|bithoraxoid-like protein|dynein light chain roadblock-type 1|dynein, cytoplasmic, light polypeptide 2A|dynein-associated protein Km23|roadblock domain-containing protein 1 |
Swissprots | Q5TC72 B1AKR5 Q96IV3 Q9NQM2 Q9NP97 |
Accessions | EAW76267 Q9NP97 AF132750 AAL75951 AF161511 AAF29126 AF165516 AAF86646 AF178431 AAK95342 AK026864 AK097281 AK294214 BAG57523 AY026513 AAK18712 BC002481 AAH02481 BC007223 BG110161 BG419592 BM561321 BM791453 BQ639804 BU163605 CB149456 XM_005260568 XP_005260625 NM_001281727 NP_001268656 NM_001281728 NP_001268657 NM_001281729 NP_001268658 NM_014183 NP_054902 NM_177953 NP_808852 NR_104032 |
Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. |
Subcellular Location | Cytoplasm, cytoskeleton. |
Tissue Specificity | High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients. {ECO:0000269|PubMed:11750132}. |
DNLC2A CRISPR/Cas9 KO Plasmid (h) - sc-413490 from Santa Cruz Biotechnology
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DNLC2A HDR Plasmid (h) - sc-413490-HDR from Santa Cruz Biotechnology
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DNLC2A Double Nickase Plasmid (h) - sc-413490-NIC from Santa Cruz Biotechnology
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DNLC2A Double Nickase Plasmid (h2) - sc-413490-NIC-2 from Santa Cruz Biotechnology
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DNLC2A CRISPR Activation Plasmid (h) - sc-413490-ACT from Santa Cruz Biotechnology
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DNLC2A CRISPR Activation Plasmid (h2) - sc-413490-ACT-2 from Santa Cruz Biotechnology
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DNLC2A Lentiviral Activation Particles (h) - sc-413490-LAC from Santa Cruz Biotechnology
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DNLC2A Lentiviral Activation Particles (h2) - sc-413490-LAC-2 from Santa Cruz Biotechnology
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DNLC2A siRNA (h) - sc-77167 from Santa Cruz Biotechnology
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DNLC2A shRNA Plasmid (h) - sc-77167-SH from Santa Cruz Biotechnology
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DNLC2A shRNA (h) Lentiviral Particles - sc-77167-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU090131 from Sigma-Aldrich
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MISSION® esiRNA - EHU094641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7590 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7590 from Sigma-Aldrich
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DYNLRB1 siRNA (Human) - CRJ3156 from Cohesion Biosciences
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DYNLRB1 - MBS8225905 from MyBioSource
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shRNA set against Human DYNLRB1(NM_014183.2) - SHH020513 from Creative biogene
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Human DYNLRB1 siRNA - orb273657 from Biorbyt
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DYNLRB1 shRNA Plasmid (Human) - CHJ3156 from Cohesion Biosciences
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DYNLRB1 miRNA 3'UTR clone - MiUTR1H-03057 from Creative biogene
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