| Gene Symbol |
METRNL
|
| Entrez Gene |
284207
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
meteorin, glial cell differentiation regulator-like
|
| Other Description |
meteorin-like protein|subfatin
|
| Swissprots |
Q86VM0 B3KSJ5 Q641Q3
|
| Accessions |
CAB58552 CBJ57243 CDM22127 EAW89833 Q641Q3 AF086149 AK093748 BAG52757 BC050568 AAH50568 BC082252 AAH82252 BC118558 AAI18559 BC118638 AAI18639 CF264755 DR760693 XM_005256349 XP_005256406 XM_006725291 XP_006725354 XM_011523562 XP_011521864 XM_011546763 XP_011545065 NM_001004431 NP_001004431
|
| Function |
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti- inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney. {ECO:0000269|PubMed:24393292, ECO:0000269|PubMed:24906147}.
|