METRNL

Gene Symbol METRNL
Entrez Gene 284207
Alt Symbol -
Species Human
Gene Type protein-coding
Description meteorin, glial cell differentiation regulator-like
Other Description meteorin-like protein|subfatin
Swissprots Q86VM0 B3KSJ5 Q641Q3
Accessions CAB58552 CBJ57243 CDM22127 EAW89833 Q641Q3 AF086149 AK093748 BAG52757 BC050568 AAH50568 BC082252 AAH82252 BC118558 AAI18559 BC118638 AAI18639 CF264755 DR760693 XM_005256349 XP_005256406 XM_006725291 XP_006725354 XM_011523562 XP_011521864 XM_011546763 XP_011545065 NM_001004431 NP_001004431
Function Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti- inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity). {ECO:0000250}.
Subcellular Location Secreted {ECO:0000250}.
Tissue Specificity Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney. {ECO:0000269|PubMed:24393292, ECO:0000269|PubMed:24906147}.

METRNL CRISPR/Cas9 KO Plasmid (h) - sc-405796 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

METRNL HDR Plasmid (h) - sc-405796-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METRNL Double Nickase Plasmid (h) - sc-405796-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METRNL Double Nickase Plasmid (h2) - sc-405796-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METRNL CRISPR Activation Plasmid (h) - sc-405796-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

METRNL CRISPR Activation Plasmid (h2) - sc-405796-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

METRNL Lentiviral Activation Particles (h) - sc-405796-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METRNL Lentiviral Activation Particles (h2) - sc-405796-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

METRNL siRNA (h) - sc-93953 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

METRNL shRNA Plasmid (h) - sc-93953-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

METRNL shRNA (h) Lentiviral Particles - sc-93953-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU100731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13220 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13220 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

METRNL siRNA (Human) - CRJ6982 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human METRNL (NM_001004431.1) - SHH340603 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human METRNL(NM_001004431.1) - SHH185447 from Creative biogene

Category siRNA
Species Reactivities Human

METRNL shRNA Plasmid (Human) - CHJ6982 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

METRNL miRNA 3'UTR clone - MiUTR1H-06217 from Creative biogene

Species Reactivities Human
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