METRNL

Gene Symbol METRNL
Entrez Gene 284207
Alt Symbol -
Species Human
Gene Type protein-coding
Description meteorin, glial cell differentiation regulator-like
Other Description meteorin-like protein|subfatin
Swissprots Q86VM0 B3KSJ5 Q641Q3
Accessions CAB58552 CBJ57243 CDM22127 EAW89833 Q641Q3 AF086149 AK093748 BAG52757 BC050568 AAH50568 BC082252 AAH82252 BC118558 AAI18559 BC118638 AAI18639 CF264755 DR760693 XM_005256349 XP_005256406 XM_006725291 XP_006725354 XM_011523562 XP_011521864 XM_011546763 XP_011545065 NM_001004431 NP_001004431
Function Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti- inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity). {ECO:0000250}.
Subcellular Location Secreted {ECO:0000250}.
Tissue Specificity Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney. {ECO:0000269|PubMed:24393292, ECO:0000269|PubMed:24906147}.

METRNL (E-12) - sc-168581 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
METRNL (E-12): sc-168581. Western blot analysis of METRNL expression in mouse testis (A) and mouse brain (B) tissue extracts and HEK293 whole cell lysate (C).

METRNL (L-14) - sc-168582 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-METRNL antibody - ab121775 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab121775, at 1:50, staining METRNL in Human kidney tissue by immunohistochemistry [Paraffin Embedded Tissues (IHC-P)].

Anti-METRNL antibody - C-terminal - ab177740 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-METRNL antibody - C-terminal (ab177740) at 1 µg/ml + Human fetal liver lysate at 10 µg

Anti-METRNL antibody - N-terminal - ab179793 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-METRNL antibody - N-terminal (ab179793) at 1 µg/ml + OVCAR-3 whole cell lysate at 10 µg

Anti-METRNL Antibody (aa32-81) - LS-C205541 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
METRNL antibody Western Blot of OVCAR-3. Antibody dilution: 1 ug/ml.

Meteorin-like/METRNL Antibody - AF7867 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows recombinant human Meteorin‑like/METRNL (1 ng/lane). PVDF membrane was probed with 0.2 µg/mL of Sheep Anti-Human Meteorin‑like/METRNL Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7867) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Meteorin‑like/METRNL at approximately 30 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

Meteorin-like/METRNL Antibody - NBP1-91064 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Meteorin-like/METRNL Antibody [NBP1-91064] - Staining of human kidney shows distinct cytoplasmic and membranous positivity in proximal tubule cells.

Anti-METRNL antibody produced in rabbit - HPA023792 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-METRNL: <B>Cat. No. HPA023792</B>: Immunohistochemical staining of human kidney shows distinct cytoplasmic and membranous positivity in proximal tubular cells.

METRNL Antibody - C-terminal region (ARP69590_P050) - ARP69590_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

METRNL Antibody - N-terminal region (ARP69591_P050) - ARP69591_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Mouse Meteorin-like/METRNL Antibody - AF6679 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Meteorin-like/METRNL in Mouse Embryo. Meteorin-like/METRNL was detected in immersion fixed frozen sections of mouse embryo (13 d.p.c.) using Sheep Anti-Mouse Meteorin-like/METRNL Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6679) at 0.6 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019 ) and counterstained with hematoxylin (blue). Specific staining was localized to muscle cells. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections .

Mouse Meteorin-like/METRNL Affinity Purified PAb, Sheep IgG - AF6679-SP from R&D Systems

Host Sheep
Clonality Polyclonal
Meteorin‑like/METRNL in Mouse Embryo. Meteorin‑like/METRNL was detected in immersion fixed frozen sections of mouse embryo (13 d.p.c.) using Sheep Anti-Mouse Meteorin‑like/METRNL Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6679) at 0.6 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). Specific staining was localized to muscle cells. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Human Meteorin-like/METRNL Antibody - AF7867 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Detection of Human Meteorin-like/ METRNL by Western Blot. Western blot shows recombinant human Meteorin-like/ METRNL (1 ng/lane). PVDF membrane was probed with 0.2 µg/mL of Sheep Anti-Human Meteorin-like/METRNL Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7867) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). A specific band was detected for Meteorin-like/METRNL at approximately 30 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8 .

Human Meteorin-like/METRNL Affinity Purified PAb, Sheep IgG - AF7867-SP from R&D Systems

Host Sheep
Clonality Polyclonal
Detection of Human Meteorin‑like/METRNL by Western Blot. Western blot shows recombinant human Meteorin‑like/METRNL (1 ng/lane). PVDF membrane was probed with 0.2 µg/mL of Sheep Anti-Human Meteorin‑like/METRNL Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7867) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Meteorin‑like/METRNL at approximately 30 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
Detection of Meteorin‑like/METRNL in Neuro‑2A Mouse Cell Line by Flow Cytometry. Neuro‑2A mouse neuroblastoma cell line was stained with Rat Anti-Mouse Meteorin‑like/METRNL PE‑conjugated Monoclonal Antibody (Catalog # IC6679P, filled histogram) or isotype control antibody (Catalog # IC013P, open histogram). To facilitate intracellular staining, cells were fixed and permeabilized with FlowX FoxP3 Fixation & Permeabilization Buffer Kit (Catalog # FC012). View our protocol for Staining Intracellular Molecules.

Meteorin-like protein antibody (FITC) - orb243010 from Biorbyt

Prices $400.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

Meteorin-like protein Antibody - abx109325 from Abbexa

Host Rabbit
Clonality Polyclonal

Meteorin-like protein Antibody (Biotin) - abx105660 from Abbexa

Host Rabbit
Clonality Polyclonal

Meteorin-like protein Antibody (FITC) - abx107077 from Abbexa

Host Rabbit
Clonality Polyclonal

Meteorin-like protein Antibody (HRP) - abx108498 from Abbexa

Host Rabbit
Clonality Polyclonal

Anti-METRNL polyclonal antibody - DPAB11535 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-METRNL (aa 261-310) polyclonal antibody - DPABH-12519 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-METRNL (aa 32-81) polyclonal antibody - DPABH-13220 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Rabbit anti-Human METRNL polyclonal antibody - DPABH-20094 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal
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