EDEM3

Gene Symbol EDEM3
Entrez Gene 80267
Alt Symbol C1orf22
Species Human
Gene Type protein-coding
Description ER degradation enhancer, mannosidase alpha-like 3
Other Description ER degradation-enhancing -mannosidase-like protein 3|ER degradation-enhancing alpha-mannosidase-like 3|ER degradation-enhancing alpha-mannosidase-like protein 3|alpha-1,2-mannosidase EDEM3
Swissprots Q9HCW1 Q7L2Y5 B7ZLZ2 Q0VGM5 Q9UFV7 B2RCH6 Q5TEZ0 Q9BZQ6
Accessions EAW91178 EAW91179 EAW91180 EAW91181 EAW91182 EAW91183 Q9BZQ6 AF288393 AAG60613 AI521228 AK000945 BAA91438 AK023095 BAB14402 AK225171 AK315118 BAG37573 AL117441 CAB55926 BC016464 AAH16464 BC070173 BC105586 AAI05587 BC144149 AAI44150 BC144150 BC160020 AAI60020 DA724785 DB292148 XM_005245499 XP_005245556 XM_011510010 XP_011508312 XM_011510011 XP_011508313 XM_011510012 XP_011508314 XM_011510013 XP_011508315 XM_011510014 XP_011508316 XM_011510015 XP_011508317 NM_025191 NP_079467
Function Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:25092655}.
Subcellular Location Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Top Pathways Protein processing in endoplasmic reticulum

EDEM3 (N-14) - sc-138249 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-EDEM3 antibody - ab67108 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EDEM3 antibody - ab69813 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EDEM3 antibody - ab129677 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-EDEM3 antibody (ab129677) at 1/100 dilution + A2058 cell lysate at 35 µg

Anti-EDEM3 antibody - ab118762 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-EDEM3 antibody (ab118762) at 1 µg/ml + Human placenta lysates at 10 µg

Anti-EDEM3 Antibody (aa774-802, AP) - LS-C256481 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EDEM3 Antibody (aa774-802, APC) - LS-C256482 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EDEM3 Antibody (aa774-802, Biotin) - LS-C256483 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EDEM3 Antibody (aa854-903) - LS-C145832 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EDEM3 antibody LS-C145832 Western blot of Placenta lysate. Antibody concentration 1 ug/ml.

Anti-EDEM3 Antibody (aa774-802, FITC) - LS-C256484 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EDEM3 Antibody (aa774-802, Azide-free, HRP) - LS-C256485 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EDEM3 Antibody (aa774-802, PE) - LS-C256486 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EDEM3 Antibody (aa774-802) - LS-C167620 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
EDEM3 Antibody western blot of A2058 cell line lysates (35 ug/lane). The EDEM3 antibody detected the EDEM3 protein (arrow).

Anti-EDEM3 Antibody (aa773-802) - LS-C321015 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EDEM3 Antibody (C-Terminus) - LS-C305960 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of EDEM3 antibody LS-X234975.

EDEM3 Antibody - NBP1-88342 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: EDEM3 Antibody [NBP1-88342] - Staining of human cerebral cortex shows distinct positivity in neuropil.

EDEM3 Antibody - NBP1-88341 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: EDEM3 Antibody [NBP1-88341] - Staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.

Anti-EDEM3 antibody produced in rabbit - E8906 from Sigma-Aldrich

Prices $63.50, $380.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Rat PC12 whole cell extract was separated on SDS-PAGE and probed with Rabbit Anti-EDEM3 (<B>Cat. No. E8906</B>). The antibody was developed with Goat Anti-Rabbit IgG, Peroxidase conjugate (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody 5 μg/mL<BR/>2. Antibody 5 μg/mL + EDEM3 immunizing peptide (human, 470-485)

Anti-EDEM3 (C-terminal) antibody produced in rabbit - E8781 from Sigma-Aldrich

Prices $63.50, $380.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Whole cell extract of human HEK-293T was separated on SDS-PAGE and blotted with Rabbit Anti-EDEM3 (C-terminal) (<B>Cat. No. E8781</B>). The antibody was developed with Goat Anti-Rabbit IgG, Peroxidase conjugate (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody 1:2,000<BR/>2. Antibody 1:2000 + EDEM3 immunizing peptide (human, 869-882)

Monoclonal Anti-EDEM3 antibody produced in mouse - E0409 from Sigma-Aldrich

Prices $57.50, $374.50
Sizes 25 µl, 200 µl
Host Mouse
Clonality Monoclonal
Clone EDEM3-1
<B>Immunoblotting</B><BR/>Cell line lysates were separated on SDS-PAGE and probed with 2 μg/mL Monoclonal Anti-EDEM3 Clone: EDEM3-1 (<B>Cat. No. E0409</B>). The antibody was developed using Goat Anti-Mouse IgG-Peroxidase (<B>Cat. No. A2304</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. HEK-293T cells; 2. HEK-293T cells overexpressing human EDEM3; 3. HeLa; 4. HEPG2; 5. MCF7; 6. NRK; 7. L8; 8. 3T3; 9. C2C12

Anti-EDEM3 antibody produced in rabbit - HPA025754 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-EDEM3: <B>Cat. No. HPA025754</B>: Immunohistochemical staining of human cerebral cortex shows distinct positivity in neuropil.

Anti-EDEM3 antibody produced in rabbit - HPA025755 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-EDEM3: <B>Cat. No. HPA025755</B>: Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.

EDEM3 antibody - C-terminal region (ARP62508_P050) - ARP62508_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

EDEM3-Antibody-C-term - AP16556b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
EDEM3 Antibody (C-term) (Cat. #AP16556b) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the EDEM3 antibody detected the EDEM3 protein (arrow).

EDEM3 Antibody - C-terminal region (OAAB11974) - OAAB11974 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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