| Gene Symbol |
EDEM3
|
| Entrez Gene |
80267
|
| Alt Symbol |
C1orf22
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ER degradation enhancer, mannosidase alpha-like 3
|
| Other Description |
ER degradation-enhancing -mannosidase-like protein 3|ER degradation-enhancing alpha-mannosidase-like 3|ER degradation-enhancing alpha-mannosidase-like protein 3|alpha-1,2-mannosidase EDEM3
|
| Swissprots |
Q9HCW1 Q7L2Y5 B7ZLZ2 Q0VGM5 Q9UFV7 B2RCH6 Q5TEZ0 Q9BZQ6
|
| Accessions |
EAW91178 EAW91179 EAW91180 EAW91181 EAW91182 EAW91183 Q9BZQ6 AF288393 AAG60613 AI521228 AK000945 BAA91438 AK023095 BAB14402 AK225171 AK315118 BAG37573 AL117441 CAB55926 BC016464 AAH16464 BC070173 BC105586 AAI05587 BC144149 AAI44150 BC144150 BC160020 AAI60020 DA724785 DB292148 XM_005245499 XP_005245556 XM_011510010 XP_011508312 XM_011510011 XP_011508313 XM_011510012 XP_011508314 XM_011510013 XP_011508315 XM_011510014 XP_011508316 XM_011510015 XP_011508317 NM_025191 NP_079467
|
| Function |
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:25092655}.
|
| Subcellular Location |
Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|
![Western Blot: EDEM3 Overexpression Lysate (Adult Normal) [NBL1-10110] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EDEM3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1634_EDEM3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10110-img0002.jpg)