PPP1R13L

Gene Symbol PPP1R13L
Entrez Gene 10848
Alt Symbol IASPP, NKIP1, RAI, RAI4
Species Human
Gene Type protein-coding
Description protein phosphatase 1, regulatory subunit 13 like
Other Description NFkB interacting protein 1|NFkB-interacting protein 1|PPP1R13B-like protein|inhibitor of ASPP protein|inhibitor of apoptosis stimulating protein of p53|protein iASPP|protein phosphatase 1, regulatory (inhibitor) subunit 13 like|relA-associated inhibitor|retinoic acid induced 4
Swissprots Q9Y290 Q2PNZ9 Q8WUF5 Q6PKF8 Q5DU71 Q6P1R7 Q5I1X4
Accessions ABC40745 EAW57343 EAW57344 EAW57345 Q8WUF5 AF078036 AAD27004 AF078037 AAD27005 AJ888472 CAI60219 AK130326 BAC85327 AY869712 AAW51146 BC001475 AAH01475 BC014499 BC020259 BC020589 AAH20589 BC032298 AAH32298 BC064913 AAH64913 DB209153 DQ986418 ABK76301 NM_001142502 NP_001135974 NM_006663 NP_006654
Function Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900}.
Subcellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear.
Tissue Specificity Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. {ECO:0000269|PubMed:10336463}.

iASPP (A-2) - sc-398566 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
iASPP (A-2): sc-398566. Western blot analysis of iASPP expression in MCF7 (A) and NCI-H1299 (B) whole cell lysates.

iASPP (C-14) - sc-74941 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

iASPP (E-16) - sc-74942 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

iASPP (49.3) - sc-53864 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

iASPP (H-300) - sc-98538 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
iASPP (H-300): sc-98538. Western blot analysis of iASPP expression in MCF7 (A) and NCI-H1299 (B) whole cell lysates.

iASPP (E-21) - sc-133686 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
iASPP (E-21): sc-133686. Western blot analysis of human iASPP transfected 293T whole cell lysate.

iASPP (2808C5a) - sc-81297 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
iASPP (2808C5a): sc-81297 Western Blot analysis of human recombinant iASPP fusion protein.

Anti-iASPP antibody [LXO49.3] - ab49805 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone LXO49.3

Anti-PPP1R13L / iASPP Antibody (clone 2808C5a) - LS-C342543 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2808C5a
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-PPP1R13L mAb.

Anti-PPP1R13L / iASPP Antibody (aa780-797) IHC-plus™ - LS-B408 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PPP1R13L / IASPP antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B408 concentration 5 ug/ml.

Anti-PPP1R13L / iASPP Antibody (aa756-805) IHC-plus™ - LS-B11881 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-PPP1R13L / iASPP Antibody (aa501-550) IHC-plus™ - LS-B11875 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-PPP1R13L / iASPP Antibody (aa780-797) - LS-C42655 from LifeSpan Bioscience

Prices $375.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP1R13L / iASPP Antibody - LS-C75210 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-PPP1R13L / iASPP Antibody (aa75-125) - LS-C288516 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R13L / iASPP Antibody (aa451-500) - LS-C109717 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PPP1R13L / IASPP antibody LS-C109717 Western blot of Transfected 293T cell lysate.

Anti-PPP1R13L / iASPP Antibody (clone 2808C5a) - LS-C184509 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2808C5a
Western blot of immunized recombinant protein using PPP1R13L antibody.

Anti-PPP1R13L / iASPP Antibody (aa75-125) IHC-plus™ - LS-B5248 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PPP1R13L / IASPP antibody IHC of human prostate, stroma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5248 concentration 5 ug/ml.

Anti-PPP1R13L / iASPP Antibody (aa778-828) - LS-C288517 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

iASPP Antibody - NBP1-77912 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: iASPP Antibody [NBP1-77912] - Shows detection of a band at ~100 kDa (arrowhead) corresponding to isoform 1 of iASPP in MCF7 whole cell lysates. Preincubation with immunizing peptide blocks specific band staining (data not shown). Approximately 35 ug of lysate was separated by 4-20% Tris Glycine SDS-PAGE. After blocking, the membrane was probed with the primary antibody diluted to 1:1,500 in 5% BLOTTO/PBS overnight at 4C. The membrane was washed and reacted with a 1:10,000 dilution of IRDye800 conjugated Gt-a-Rabbit IgG [H&L] for 45 min at room temperature (800 nm channel, green). Molecular weight estimation was made by comparison to prestained MW markers.

iASPP Antibody - H00010848-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: iASPP Antibody [H00010848-B01] - analysis of PPP1R13L expression in transfected 293T cell line by PPP1R13L MaxPab polyclonal antibody (B01). Lane1: PPP1R13L transfected lysate (89.10 KDa). Lane2: Non-transfected lysate.

iASPP Antibody - H00010848-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: iASPP Antibody [H00010848-B01P] - Analysis of PPP1R13L expression in transfected 293T cell line by PPP1R13L polyclonal antibody. Lane1:PPP1R13L transfected lysate(91.08 KDa). Lane2:Non-transfected lysate.

iASPP Antibody - NB100-88155 from Novus Biologicals

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: iASPP Antibody [NB100-88155] - Detection of Human iASPP on HeLa whole cell lysate using NB100-88155. iASPP was also immunoprecipitated by rabbit anti-iASPP antibody NB100-88156.

iASPP Antibody - NBP2-38879 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: iASPP Antibody [NBP2-38879] - Staining of human skin shows moderate cytoplasmic positivity in epidermal cells.

iASPP Antibody - H00010848-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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